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Medchemexpress LLC (Z)-4EGI-1 | 901787-88-0 | 98.0% | 451.28 | 50 MG
Supplier: Medchemexpress LLC HY19831A50MG
(Z)-4EGI-1 is the Z-isomer of 4EGI-1 and acts as an inhibitor of eIF4E/eIF4G interaction and translation initiation. It binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. It also exhibits anticancer activity.
- Inhibitor of eIF4E/eIF4G interaction and translation initiation.
- Effectively binds to eIF4E.
- Has anticancer activity.
- Inhibits cancer cell proliferation (IC50 values of 15.3 μM for CRL-2351 breast cells and 11.6 μM for CRL-2813 melanoma cells).
- Markedly reduces expressions of regulatory proteins: cyclin D1, cyclin E, and Survivin in CRL-2813 melanoma cells at 15-30 μM for 6 hours.
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