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Apexbio Technology LLC Z-DEVD-FMK 210344-95-9 25mg
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Catalog No. 5000063122
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Z-DEVD-FMK (CAS 210344-95-9) is a tetrapeptide inhibitor primarily targeting caspase-3 a protease involved in apoptotic neuronal cell death Beyond caspase-3 inhibition Z-DEVD-FMK also directly suppresses calpain-mediated proteolysis notably reducing calpain-induced spectrin degradation In vitro studies confirm Z-DEVD-FMK attenuates necrotic neuronal death independently of caspase-3 activity In vivo following traumatic brain injury (TBI) or cerebral ischemia administration of Z-DEVD-FMK limits lesion size reduces tissue damage and improves functional neurological outcomes likely due to combined inhibition of caspase-3 and calpain pathways

Catalog No. 50-000-63122 Supplier Apexbio Technology LLC Supplier No. A192025
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Z-DEVD-FMK (CAS 210344-95-9) is a tetrapeptide inhibitor primarily targeting caspase-3 a protease involved in apoptotic neuronal cell death Beyond caspase-3 inhibition Z-DEVD-FMK also directly suppresses calpain-mediated proteolysis notably reducing calpain-induced spectrin degradation In vitro studies confirm Z-DEVD-FMK attenuates necrotic neuronal death independently of caspase-3 activity In vivo following traumatic brain injury (TBI) or cerebral ischemia administration of Z-DEVD-FMK limits lesion size reduces tissue damage and improves functional neurological outcomes likely due to combined inhibition of caspase-3 and calpain pathways

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