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Apexbio Technology LLC Z-FA-FMK 105637-38-5;197855-65-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A81705.1
Z-FA-FMK is a peptidyl fluoromethyl ketone inhibitor targeting cysteine proteases specifically cathepsins such as cathepsin B and certain caspases It does not require a P1 aspartate residue for inhibition Mechanistically Z-FA-FMK suppresses the enzyme activity of effector caspases (including caspases-2 -3 -6 and -7) but shows minimal impact on initiator caspases (caspase-8 and caspase-10) and only partial attenuation of caspase-9 activity As a negative control inhibitor Z-FA-FMK is regularly applied in apoptosis research to differentiate specific caspase-dependent signaling pathways and to assess the role of cathepsins and caspases in biological contexts such as cell death mechanisms and related pathways
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