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Apexbio Technology LLC Z-Guggulsterone 39025-23-5 5mg
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Catalog No. 5000091966
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Z-Guggulsterone (CAS 39025-23-5) is a small-molecule antagonist targeting multiple steroid hormone receptors including glucocorticoid (IC50 1740 nM) mineralocorticoid (IC50 1000 nM) androgen (IC50 220 nM) progesterone (EC50 1200 nM) estrogen (EC50 5000 nM) and farnesoid X (IC50 50000 nM) receptors It is designed to modulate these targets thereby influencing steroid receptor-mediated signaling pathways Z-Guggulsterone exerts its biological activity primarily through inhibition of receptor-mediated angiogenic processes In cell-based studies Z-Guggulsterone demonstrates dose- and time-dependent inhibition of cellular migration and tube formation in DU145 prostate cancer cells and human umbilical vein endothelial cells (HUVEC) Based on these pharmacological properties Z-Guggulsterone holds research potential in studies of tumor-associated angiogenesis and steroid receptor signaling

Catalog No. 50-000-91966 Supplier Apexbio Technology LLC Supplier No. B74315
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Z-Guggulsterone (CAS 39025-23-5) is a small-molecule antagonist targeting multiple steroid hormone receptors including glucocorticoid (IC50 1740 nM) mineralocorticoid (IC50 1000 nM) androgen (IC50 220 nM) progesterone (EC50 1200 nM) estrogen (EC50 5000 nM) and farnesoid X (IC50 50000 nM) receptors It is designed to modulate these targets thereby influencing steroid receptor-mediated signaling pathways Z-Guggulsterone exerts its biological activity primarily through inhibition of receptor-mediated angiogenic processes In cell-based studies Z-Guggulsterone demonstrates dose- and time-dependent inhibition of cellular migration and tube formation in DU145 prostate cancer cells and human umbilical vein endothelial cells (HUVEC) Based on these pharmacological properties Z-Guggulsterone holds research potential in studies of tumor-associated angiogenesis and steroid receptor signaling

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