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Apexbio Technology LLC Z-IETD-FMK 210344-98-2 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B32325.1
Z-IETD-FMK (CAS 210344-98-2) is a cell-permeable peptide-derived inhibitor targeting caspase-8 It reduces T-cell proliferation induced by stimuli such as phytohemagglutinin (PHA) or anti-CD3/anti-CD28 antibodies primarily through downregulation of CD25 expression without affecting IL-2 or IFN- secretion Additionally Z-IETD-FMK inhibits NF- B activation at higher concentrations (100 M) Studies also demonstrate its protective effects against TRAIL-induced apoptosis by inhibiting processing of procaspases-2 -3 -9 and PARP cleavage in cancer cell lines such as HCT116 and SW480
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