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Apexbio Technology LLC Zacopride hydrochloride 101303-98-4 10mg
Supplier: Apexbio Technology LLC B685810
Zacopride hydrochloride (CAS 101303-98-4) is a small molecule that functions as a high-affinity antagonist at 5-HT sub 3 /sub receptors ( i K sub i /sub /i 0 38 nM) and as an agonist at 5-HT sub 4 /sub receptors ( i K sub i /sub /i 373 nM) These receptors are subtypes of serotonin (5-HT) receptors involved in modulating neurotransmission in central and peripheral systems In human adrenocortical tissue zacopride hydrochloride induces aldosterone secretion in a dose-dependent manner with an effective concentration as low as 10 sup -10 /sup mol/L and half-maximal stimulation at 7 10 sup -8 /sup mol/L In vivo oral administration of 400 g zacopride increased plasma aldosterone without affecting renin adrenocorticotropic hormone or cortisol Zacopride hydrochloride is valuable for studying serotonergic regulation of adrenal steroidogenesis and receptor pharmacology
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