Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC ZD 7288(Synonyms: ZD7288, Zatebradine hydrochloride, HCN channel inhibitor ZD7288), 5mg, CAS: 133059-99-1.
Supplier: Apexbio Technology LLC B65425
ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?