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Apexbio Technology LLC ZD 7288 5MG
SDP

Supplier:  Apexbio Technology LLC B65425

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ZD 7288 (CAS 133059-99-1) is a selective inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels These channels mediate Na and K currents notably the hyperpolarization-activated current (I h) contributing to neuronal excitability and rhythmic activity ZD 7288 reduces I h in a concentration-dependent voltage- and time-sensitive manner as demonstrated in rat facial motoneurons (IC 50 0 2 M) and hippocampal CA1 pyramidal neurons Additionally it inhibits T-type calcium currents in rat CA1 pyramidal cells ZD 7288 is utilized in research investigating neuronal excitability mechanisms pain signaling and chronic visceral pain models

Catalog No. 50-000-60481


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