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Medchemexpress LLC Α-Zearalenol-d4 | 1778734-73-8 | 500 UG
Supplier: Medchemexpress LLC HYN6710S500UG
Α-Zearalenol-d4 is a deuterated labeled α-Zearalenol. Α-Zearalenol is a mycotoxin with high affinity for the estrogen receptors (ER), it is a derivative of zearalenone (ZEN), and causes reproductive disorders in animals due to its xenoestrogenic effects.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules.
- Deuteration has potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Shows the highest RPE (90.5%) at 9.37 μM α-ZOL exposure in MFC-7 cells.
- Induces an increase of cell viability on MCF-7 cells mainly after 72 hours of treatment.
- Increases MCF7 cell population in the S phase and in the G2/M phase.
- Reduces the expression of TNF-α.
- Combines with β-ZOL showing an antagonistic effect on inflammation for IL-1β and acts synergic for IL-8 at high toxin concentrations.
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