STEMCELL Technologies Zebularine, Size: 10 mg

Supplier:  STEMCELL Technologies 72902

Zebularine, a cytidine analog, is a DNA methylation inhibitor that acts by forming a covalent complex with DNA methyltransferases (DNMTs; Zhou et al.).DIFFERENTIATION· Induces cardiomyocyte differentiation from rat bone marrow mesenchymal stem cells (MSCs; Naeem et al.). CANCER RESEARCH· Reduces proliferation of the cancer cell lines TK6, Jurkat, KG-1, and HCT116 (Stresemann et al.).· Inhibits cell proliferation in T24 bladder carcinoma cells (Ben-Kasus et al.).· In combination with the histone deacetylase inhibitor SAHA, reduces cell proliferation and increases apoptosis in pancreatic cancer cell lines (Neureiter et al.).· Inhibits cell proliferation and induces apoptosis in human acute myeloid leukemia cells in vitro (Scott et al.).· Increases the proportion of cells with cancer stem cell properties in subpopulations of human cancer cells and liver cancer cell lines (Marquardt et al.).

Catalog No. 50-197-5998

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov