Medchemexpress LLC Zenidolol hydrochloride | 72795-01-8 | 99.7% | 313.86 | 100 MG

Supplier:  Medchemexpress LLC 100MGHY13951

Zenidolol hydrochloride (ICI-118551) is a highly selective β2 adrenergic receptor antagonist, demonstrating potent inhibition with Kis of 0.7, 49.5, and 611 nM for β2, β1, and β3 receptors, respectively. It is for research use only.

• Highly selective β2 adrenergic receptor antagonist
• Inhibits cAMP accumulation with an IC50 of 1.7 μM in IMCD cells
• Induces prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO (at 10 μM)
• Has significant effects on beat duration in failing human heart, reducing time-to-peak contraction and time-to-90% relaxation compared with basal contraction
• Negative inotropic effect is not cAMP-related
• Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects
• Reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure when injected into the jugular vein of mice (at 0.2 mg/kg)

Catalog No. 50-003-64951