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Medchemexpress LLC Zinc05007751 | 591239-68-8 | 99.3% | 304.30 | 5 MG
SDP

Catalog No. 5000364285
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ZINC05007751 is a potent and selective NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. It exhibits antiproliferative activity across a range of human cancer cell lines, such as MDA-MB-231, PEO1, NCI-H1299, and HCT-15. It shows synergistic effects when combined with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line (PEO1) and is highly selective, showing no significant activity against NEK2, NEK7, and NEK9.

  • Potent and selective NEK6 inhibitor
  • Exhibits antiproliferative activity against human cancer cell lines
  • Shows synergistic effects with Cisplatin and Paclitaxel in BRCA2 mutated ovarian cancer cells
  • Induces perturbation of PEO1 cell cycle
  • Highly selective against NEK2, NEK7, and NEK9
  • Provided as a brown to black solid

Catalog No. 50-003-64285 Supplier Medchemexpress LLC Supplier No. 5MGHY122639
May include imposed supplier surcharges.
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ZINC05007751 is a potent and selective NIMA-related kinase NEK6 inhibitor with an IC50 of 3.4 μM. It exhibits antiproliferative activity across a range of human cancer cell lines, such as MDA-MB-231, PEO1, NCI-H1299, and HCT-15. It shows synergistic effects when combined with Cisplatin and Paclitaxel in a BRCA2 mutated ovarian cancer cell line (PEO1) and is highly selective, showing no significant activity against NEK2, NEK7, and NEK9.

  • Potent and selective NEK6 inhibitor
  • Exhibits antiproliferative activity against human cancer cell lines
  • Shows synergistic effects with Cisplatin and Paclitaxel in BRCA2 mutated ovarian cancer cells
  • Induces perturbation of PEO1 cell cycle
  • Highly selective against NEK2, NEK7, and NEK9
  • Provided as a brown to black solid

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