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Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 | C21H30Cl2N2O3 | 50 MG
Supplier: Medchemexpress LLC HY101038A50MG
ZK756326 dihydrochloride is a nonpeptide agonist of the CC chemokine receptor CCR8 used as a research tool to study CCR8 signaling. It inhibits binding of the CCR8 ligand I-309 (CCL1) with an IC50 of 1.8 μM, functions as a full agonist that increases intracellular calcium, and stimulates extracellular acidification in CCR8-expressing cells.
- Nonpeptide CCR8 agonist for receptor activation studies.
- IC50 for CCR8 binding inhibition: 1.8 μM.
- Full agonist - induces dose-dependent intracellular calcium increase.
- Shows >28-fold specificity versus a 26-GPCR panel at 50 μM.
- Reduced selectivity observed versus certain serotonergic and α2A-adrenergic receptors.
- Purity 99.87%, white to off-white solid.
- Available as multiple solid sizes and 10 mM solution in DMSO.
- Storage: 4°C sealed; in solvent -80°C (6 months), -20°C (1 month).
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