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Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 100 MG

Supplier: Medchemexpress LLC HY126428100MG
ZL0580, a structurally close analog of ZL0590, induces epigenetic suppression of HIV via selectively binding to BD1 domain of BRD4. It induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
- Induces epigenetic suppression of HIV
- Selectively binds to BD1 domain of BRD4
- Inhibits Tat transactivation and transcription elongation
- Induces repressive chromatin structure at the HIV promoter
- Suppresses HIV in primary CD4+ T cells
- Exhibits low toxicity in cell viability assays
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