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Medchemexpress LLC ZL0580 | 2377151-10-3 | 99.4% | 532.53 | 50 MG
Supplier: Medchemexpress LLC HY12642850MG
ZL0580 is a structurally similar analog of ZL0590. It induces epigenetic suppression of HIV by selectively binding to the BD1 domain of BRD4. This compound suppresses HIV by inhibiting Tat transactivation and transcription elongation, and by inducing repressive chromatin structure at the HIV promoter. It is intended for research use only.
- Induces epigenetic suppression of HIV
- Selectively binds to BD1 domain of BRD4
- Inhibits Tat transactivation and transcription elongation
- Induces repressive chromatin structure at the HIV promoter
- Demonstrates low toxicity at effective concentrations (e.g., 8 μM in PBMCs)
- Suppresses both PMA-stimulated and basal HIV transcription
- Shows almost complete loss of productive HIV infection in CD4+ T cells at 8 μM
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