Medchemexpress LLC ZLN024 hydrochloride | 1883548-91-1 | 98.5% | 361.69 | 100 MG

Supplier:  Medchemexpress LLC HY16708A100MG

ZLN024 hydrochloride is an allosteric activator of AMPK. It directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1, and AMPK α2β2γ1 heterotrimers.

• Allosterically stimulates active AMPK heterotrimers and inactive α1 subunit truncations.
• AMPK activation requires pre-phosphorylation of Thr-172 and protects AMPK Thr-172 against dephosphorylation by PP2Cα.
• Activates AMPK in L6 myotubes, stimulating glucose uptake and fatty acid oxidation without increasing the ADP/ATP ratio.
• Increases the activity of α1β1γ1 by 1.5-fold (EC50 of 0.42 μM), α2β1γ1 by 1.7-fold (EC50 of 0.95 μM), α1β2γ1 by 1.7-fold (EC50 of 1.1 μM), and α2β2γ1 by 1.6-fold (EC50 of 0.13 μM).
• Improves glucose tolerance in C57BKS db/db mice after 4 weeks of treatment.
• Reduces fasting blood glucose by 15%, liver tissue weight, triacylglycerol, and total cholesterol content in mice.

Catalog No. 50-003-93530