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Apexbio Technology LLC ZM 39923 HCl 1021868-92-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A41515.1
ZM 39923 HCl (CAS 1021868-92-7) is a small molecule that selectively inhibits Janus kinases JAK1 and JAK3 displaying pIC50 values of 4 4 and 7 1 respectively As JAK family kinases play a pivotal role in cytokine-mediated signaling via the JAK-STAT pathway ZM 39923 HCl is frequently employed to investigate signal transduction mechanisms linked to hematological malignancies autoimmune conditions and inflammatory disorders The compound also inhibits tissue transglutaminase 2 (TGM2) with an IC50 of 10 nM and exhibits equivalent inhibition of EGFR In cellular studies ZM 39923 HCl modulates T cell proliferation and apoptosis and affects pathways involving VEGF and TGF 2 underscoring its utility in cytokine oncology and cell biology research
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