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Medchemexpress LLC Zm223 hydrochloride | 2438679-27-5 | 98.9% | 538.99 g·mol⁻¹ | C23H18ClF3N4O2S2 | 50 MG
Supplier: Medchemexpress LLC HY101790A50MG
ZM223 hydrochloride is an orally active, potent non-covalent inhibitor of the NEDD8-activating enzyme (NAE) with demonstrated anticancer activity in cell-based assays. It inhibits proliferation of HCT-116 and U-2OS cells at low-nanomolar IC50s and alters NEDD8 conjugation, producing decreased NEDD8 levels and accumulation of UBC12.
- Orally active non-covalent NAE inhibitor.
- Potent cellular activity (IC50 ≈ 100-122 nM in reported assays).
- Modulates NEDD8 conjugation pathway, useful for mechanistic studies.
- High purity suitable for preclinical research (≈ 98.9%).
- Solid, white to off-white material with recommended cold storage for stock solutions.
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