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Medchemexpress LLC Zm323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 25 MG
Supplier: Medchemexpress LLC 25MGHY15467A
ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. This anilinoquinazoline potently inhibits VEGFR2 (KDR) tyrosine kinase activity, showing excellent selectivity over other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation and VEGFR2 tyrosine phosphorylation.
- Potent and selective VEGFR2 inhibitor (IC50 < 2 nM)
- Inhibits VEGFR2 (KDR) tyrosine kinase activity
- Excellent selectivity over other receptor tyrosine kinases
- Inhibits VEGF-A-induced endothelial cell proliferation (IC50 = 8 nM)
- Inhibits VEGFR2 tyrosine phosphorylation
- Blocks activation of VEGFR-2, while sparing VEGFR-1, EGFR, PDGFR, and HGF receptor
- For research use only
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