Cayman Chemical ZngIbrosIde R1 10mg

Supplier:  Cayman Chemical 3413010 MG

A PI3K inhibitor (IC50 1 nM) selective for PI3K over PI3Ka PI3KB and PI3KY (IC50s 10000 nM for all) as well as a panel of 192 additional kinases and a panel of 70 ion channels and transporters at 1 UM inhibits primary human B cell proliferation (IC50 0.2 nM) and memory T cell cytokine production (IC50s 0.2-1.5 nM) inhibits the differentiation of naïve isolated human T cells into Th1 Th2 or Th17 T helper cells inhibits the proliferation of JeKo-1 Mino Rec-1 and JVM-2 lymphoma cells (IC50s 50s 2-8 nM) reduces intratumoral phosphorylation of Akt and tumor growth in a Pfeiffer mouse xenograft model from 0.1-10 mg/kg reduces proteinuria lymphadenopathy and the severity of skin lesions in an MRL/MpJ-Fas lpr mouse model of spontaneous SLE at 3 mg/kg reduces salivary levels of TNFSF13B and plasma levels of anti-SSA and anti-SSB autoantibodies in a NOD.ShiLtJ mouse model of Sjögrens syndrome

Catalog No. 50-294-7698