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STEMCELL Technologies Zoledronic Acid (Hydrate), Size: 50 mg
Supplier: STEMCELL Technologies 73572
Zoledronic acid is a nitrogen-containing bisphosphonate that inhibits farnesyl diphosphate (FPP) synthase (IC₅₀ = 5 nM), thereby preventing protein prenylation and osteoclast-mediated bone resorption (Dunford et al.). In addition, it has a high affinity for hydroxyapatite (Ki = 3.5 μM) which allows it to bind directly to mineralized bone (Nancollas et al.). This product is supplied as the hydrate form of the molecule.CANCER RESEARCH· Inhibits proliferation, angiogenesis, and adhesion to bone, in several cancer cell lines (Li & Davis; Zekri et al.).· Inhibits breast and prostate carcinoma cell invasion in vitro (Boissier et al.; Li & Davis).· Induces apoptosis of osteoclastoma cells in vitro (Benford et al.).
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