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Cayman Chemical Zopolrestat 10mg
Supplier: Cayman Chemical 2918510 MG
A potent aldose reductase inhibitor (IC50s = 1.9 and 41 nM for the human placenta and rat lens enzymes, respectively); inhibits sorbitol accumulation in human and rat erythrocytes (IC50s = 370 and 220 nM, respectively); inhibits ethanol-induced aldose reductase activity and lipid accumulation in HepG2 cells at 50 μM; reduces sciatic nerve, retina, and lens accumulation of sorbitol in a rat model of STZ-induced diabetes at 50 mg/kg; reduces protein excretion and maintains lens transparency and myo-inositol content in rats with STZ-induced diabetes at 100 mg/kg; inhibits GLOI (Ki = 18 μM)
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