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Cayman Chemical ZotarolImus 10mg
Supplier: Cayman Chemical 2924610 MG
A macrocyclic lactone immunosuppressant; binds to FKBP12 (IC50 = 2.57 nM); inhibits proliferation of human PBMCs, rat splenocytes, and human coronary artery smooth muscle cells (IC50s = 7, 1,337, and 0.8 nM, respectively); has immunosuppressive activity in a one-way mixed lymphocyte reaction using human or rat lymphocytes (IC50s = 1.2 and 1,465 nM, respectively); reduces symptom severity in a rat model of EAE (ED50 = 1.17 mg/kg per day); delays cardiac allograft rejection in rats (ED50 = 3.71 mg/kg per day); inhibits neointimal formation and reduces stenosis in pig coronary arteries when applied at 10 UG/mm to stainless steel balloon expandable stents with phosphorylcholine in a model of restenosis
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