Apexbio Technology LLC Zotarolimus(ABT-578) 221877-54-9 25mg

Supplier:  Apexbio Technology LLC B478625

Zotarolimus ABT-578 is a small-molecule inhibitor targeting the immunophilin FKBP12 It is designed to form a complex with FKBP12 thereby inhibiting mTOR pathway signaling and suppressing the proliferation of T-cells vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) Zotarolimus ABT-578 exerts its biological activity primarily through mTOR pathway inhibition In cell-based studies zotarolimus demonstrates nanomolar-level inhibitory potency against human coronary artery cell proliferation and T-cell activation Based on these pharmacological properties zotarolimus ABT-578 holds research potential in vascular restenosis prevention neointimal hyperplasia reduction and immunological studies involving T-cell function

Catalog No. 50-000-90843