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Medchemexpress LLC Zotatifin (eFT226) | 2098191-53-6 | 99.7% | 487.55 | 2 MG
Supplier: Medchemexpress LLC HY1121632MG
Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. It shows robust antiviral effects by effectively reducing viral infectivity through inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM) and induces cell apoptosis.
- Potent, selective, and well-tolerated eIF4A inhibitor.
- Promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM).
- Interferes with the assembly of the eIF4F initiation complex.
- Shows robust antiviral effects, reducing viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).
- Induces cell apoptosis.
- Appearance: solid, white to light yellow.
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