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Medchemexpress LLC Zotatifin (eFT226) | 2098191-53-6 | 99.7% | 487.55 | 2 MG
SDP

Catalog No. 5000436251
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Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. It shows robust antiviral effects by effectively reducing viral infectivity through inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM) and induces cell apoptosis.

  • Potent, selective, and well-tolerated eIF4A inhibitor.
  • Promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM).
  • Interferes with the assembly of the eIF4F initiation complex.
  • Shows robust antiviral effects, reducing viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).
  • Induces cell apoptosis.
  • Appearance: solid, white to light yellow.

Catalog No. 50-004-36251 Supplier Medchemexpress LLC Supplier No. HY1121632MG
May include imposed supplier surcharges.
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Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex. It shows robust antiviral effects by effectively reducing viral infectivity through inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM) and induces cell apoptosis.

  • Potent, selective, and well-tolerated eIF4A inhibitor.
  • Promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs (IC50=2 nM).
  • Interferes with the assembly of the eIF4F initiation complex.
  • Shows robust antiviral effects, reducing viral infectivity by inhibiting SARS-CoV-2 NP protein biogenesis (IC90=37 nM).
  • Induces cell apoptosis.
  • Appearance: solid, white to light yellow.

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