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Medchemexpress LLC Zotizalkib | 2648641-36-3 | 98.0% | C21H20F3N5O3 | 10MG
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Supplier:  Medchemexpress LLC HY13927910MG

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Zotizalkib (TPX-0131) is a potent, CNS-penetrant, orally active inhibitor of anaplastic lymphoma kinase (ALK) designed for research use. It demonstrates low-nanomolar activity against wild-type ALK and a broad spectrum of resistance mutations and has shown antitumor effects in preclinical studies.

  • Potent ALK inhibition (IC50 ≈ 1.4 nM).
  • CNS-penetrant, supporting brain exposure in preclinical models.
  • Active against multiple ALK resistance mutations.
  • High chemical purity (~98.0%).
  • Chemical formula C21H20F3N5O3 and molecular weight 447.41 g/mol.
  • Supplied for research use only; not for human or clinical use.

Catalog No. 50-002-60892


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