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Medchemexpress LLC ZT-1a | 212135-62-1 | 99.8% | 445.73 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY136532100MG

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ZT-1a is a potent, non-ATP-competitive, and selective SPAK inhibitor. It inhibits SPAK activity and decreases SPS1-related proline/alanine-rich kinase (SPAK)-dependent phosphorylation of Na-K-2Cl cotransporter (NKCC1) and K-Cl cotransporters (KCCs).

  • Potent, non-ATP-competitive, and selective SPAK inhibitor
  • Inhibits SPAK activity with IC50s of 44.3, 35.0, and 46.7 μM
  • Inhibits Na-K-2Cl cotransporter (NKCC1)
  • Stimulates K-Cl cotransporters (KCCs)
  • Decreases SPAK-dependent phosphorylation
  • For research use only

Catalog No. 50-003-51793


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