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Cayman Chemical ZunsemetInIb 10mg
SDP

Catalog No. 502945900
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An MK2-biased p38α MAPK inhibitor; selectively inhibits p38α MAPK-dependent activation of MK2 over p38α MAPK-dependent activation of MK5 and ATF2 by 750- and 700-fold, respectively; greater than 350-fold selective for p38α MAPK over a panel of 193 other kinases at 5 µM; reduces LPS-induced increases in the levels of mRNA encoding Il-1β in isolated mouse BMMs at 10 µM; reduces body weight loss, neutrophilia, and the number of osteoclasts at trabecular and cortical bone surfaces in a model of NOMIDc using Nlrp3fl(D301N)/+;CreER mice; enhances decreases in tumor volume and increases in survival in an autochthonous KPC murine PDAC model when used in combination with FIRINOX

Catalog No. 50-294-5900 Supplier Cayman Chemical Supplier No. 4186310 MG
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An MK2-biased p38α MAPK inhibitor; selectively inhibits p38α MAPK-dependent activation of MK2 over p38α MAPK-dependent activation of MK5 and ATF2 by 750- and 700-fold, respectively; greater than 350-fold selective for p38α MAPK over a panel of 193 other kinases at 5 µM; reduces LPS-induced increases in the levels of mRNA encoding Il-1β in isolated mouse BMMs at 10 µM; reduces body weight loss, neutrophilia, and the number of osteoclasts at trabecular and cortical bone surfaces in a model of NOMIDc using Nlrp3fl(D301N)/+;CreER mice; enhances decreases in tumor volume and increases in survival in an autochthonous KPC murine PDAC model when used in combination with FIRINOX

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