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Medchemexpress LLC Zunsemetinib | 1640282-42-3 | 99.99% | 513.92 | 250 MG
Supplier: Medchemexpress LLC 250MGHY139553
Zunsemetinib (CDD-450) is an orally active and selective p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) pathway inhibitor. It is utilized in research for immuno-inflammatory diseases and selectively blocks p38α MAPK activation of the proinflammatory kinase MK2.
- Used for research of immuno-inflammatory diseases.
- Selectively blocks p38α MAPK activation of the proinflammatory kinase MK2.
- Inhibits in vitro osteoclast formation induced by RANKL.
- Decreases IL-1β expression by promoting IL-1β mRNA degradation.
- Reduces IL-1β secretion and promotes IL-1β mRNA instability.
- Blocks LPS-induced TNF-α expression in vivo.
- Increases bone density in vivo.
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