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Medchemexpress LLC ZXH-1-161 | 2407654-51-5 | 98.4% | 468.51 | 100 MG
Supplier: Medchemexpress LLC HY147158100MG
ZXH-1-161 is a potent CRBN modulator that selectively induces the degradation of GSPT1 in a CRBN-dependent manner. It can inhibit the proliferation of multiple myeloma cells and exhibits antitumor activity.
- Potent CRBN modulator.
- Selectively induces degradation of GSPT1.
- Inhibits proliferation of multiple myeloma cells.
- Exhibits antitumor activity.
- IC50 of 0.039 μM in MM1.S wild-type cells for antiproliferative activity.
- Induces GSPT1 degradation in MM1.S cells at 0.01-10 μM (4 h).
- Reduces GSPT1 levels in MM1.S cells in a dose-dependent manner.
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