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Medchemexpress LLC ZZW-115 hydrochloride | 10122-45-9 | 98.09% | 573.97 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY111838A

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ZZW-115 hydrochloride is a potent NUPR1 inhibitor with a Kd of 2.1 μM. It induces tumor cell death through necroptosis and apoptosis, demonstrating anticancer activity.

  • Effective in killing cancer cells with IC50 values ranging from 0.84 μM to 4.93 μM in various cell lines in vitro.
  • Induces pancreatic cell death by necrosis and apoptosis, leading to decreased ATP production and increased ROS overproduction.
  • Causes higher LDH release and greater caspase 3/7 activity in a concentration-dependent manner.
  • Inhibits the growth of pancreatic xenografted tumors in mice when administered at 0.5-5 mg/kg daily for 30 days via injection.
  • Dosage of 5 mg/kg for 30 days resulted in almost unmeasurable tumor sizes in some cases of C57BL/6 mice.
  • Caused tumors to progressively decrease and almost disappear by the end of treatment in nude mice xenografted with MiaPaCa-2 cells at a 5 mg/kg dose.

Catalog No. 50-004-39504


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