Matrix Modifiers
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Sigma Aldrich Fine Chemicals Biosciences L Anserne ntrate salt hy250MG
L Anserne ntrate salt hy250MG
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Medchemexpress LLC PD-118057 | 313674-97-4 | 98.06% | 386.27 | 50 MG
PD-118057 is an activator of the hERG channel that does not induce hERG blockade. It operates by activating the hERG channel, thereby helping to suppress changes in membrane excitability. Studies have shown that it specifically enhances hERG current and inhibits action potential duration in guinea pig ventricular muscle and cardiomyocytes. Additionally, it can reverse current inhibition caused by certain agents.
- Activates the hERG channel without causing blockade.
- Suppresses changes in membrane excitability.
- Increases hERG current.
- Inhibits action potential duration in ventricular muscle.
- Reverses current inhibition induced by specific substances.
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