Nucleosides and Analogues
Medchemexpress LLC L-Uridine | 26287-69-4 | 244.20 | 250 MG
L-Uridine is an enantiomer of the normal RNA constituent D-uridine. It can be isolated from the Polyporaceae fungus *Poria cocos* (Schw.) and acts as a phosphate acceptor for nucleoside phosphotransferases. In vitro, L-uridine (7 min) is converted to 5'-L-uridylic acid, with a Km value of 28 mM.
- Enantiomer of D-uridine
- Isolated from *Poria cocos* (Schw.)
- Acts as a phosphate acceptor for nucleoside phosphotransferases
- High purity (99.81%)
- Available as a solid
- Soluble in various in vitro dissolution methods
- Stable under specified storage conditions
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.9% | 681.49 | 5 MG
Sonidegib diphosphate, also known as Erismodegib diphosphate, is a potent and selective Smoothened (Smo) antagonist. It works by directly interacting with Smo to reduce the expression of downstream Hedgehog (Hh) signaling targets. This compound has shown dose-related antitumor activity in medulloblastoma mouse models, effectively inhibiting tumor growth and causing regression at higher doses. It is for research use only.
- Potent and selective Smo antagonist
- Interacts directly with Smo to reduce expression of downstream Hh signaling targets
- Inhibits the Hh pathway in CD34+ chronic phase chronic myeloid leukemia (CML) cells
- Reduces the number and self-renewal capacity of CML leukemia stem cells (LSC)
- Demonstrates dose-related antitumor activity in medulloblastoma allograft mouse models
- Significantly inhibits tumor growth and affords regression at higher doses
Medchemexpress LLC Oxidized low density lipoprotein (mouse) | ≥98% | 1 MG
Oxidized low density lipoprotein (mouse) (Mouse ox-LDL) is an oxidized low density lipoprotein (LDL). It induces atherosclerosis (AS) by facilitating endothelial dysfunction and accelerating the VSMCs growth and migration, making it suitable for constructing an in vitro model of AS.
- Induces atherosclerosis (AS)
- Facilitates endothelial dysfunction
- Accelerates VSMCs growth and migration
- Can be used to construct an in vitro model of AS
- Upregulates mRNA and protein expressions of long noncoding RNA TUG1 and receptor tyrosine kinase-like orphan receptor 2 (ROR2)
- Promotes the proliferation of HA-VSMCs
- Enhances migration and invasion abilities
- Increases the expressions of metastasis-related proteins β-catenin and Vimentin in human aortic vascular smooth muscle cells
Medchemexpress LLC Adenosine 5'-diphosphoribose sodium | 68414-18-6 | MFCD00136017 | 99.5% | 581.30 g/mol | C15H22N5NaO14P2 | 25 MG
Adenosine 5′-diphosphoribose sodium is a high-purity nucleotide metabolite used in biochemical and cellular research to activate TRPM2 Ca2+-permeable channels and investigate nucleotide-mediated signaling. Supplied as a sodium salt in solid and solution formats, it includes solubility guidance for water and DMSO and storage recommendations for sealed, moisture-free conditions.
- High purity: 99.5% by HPLC.
- Soluble in water and DMSO with recommended concentrations for in vitro use.
- Available as solid (5-100 mg) and 10 mM solution in water.
- Used to activate TRPM2 channels and study nucleotide signaling pathways.
- Store sealed, away from moisture; follow recommended temperature guidelines.
Cambridge Isotope Laboratories 5-Fluoro-2-deoxyuridine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 95% 100 umol
5-Fluoro-2-deoxyuridine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 95% 100 umol
Cayman Chemical 2-DeoxyurIdIn 1g
A pyrimidine nucleoside; has been used as a precursor in the synthesis of antiviral deoxyuridine derivatives, including idoxuridine
Cambridge Isotope Laboratories 2-Fluoro-2-deoxycytidine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 90% 100 umol
2-Fluoro-2-deoxycytidine 5-triphosphate ammonium salt (unlabeled) (in solution) CP 90% 100 umol
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | MFCD28041154 | 97.0% | 267.25 | 100 MG
3′-Deoxyguanosine is a derivative of Guanosine. It interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. It exhibits moderate displacement activity for [3H]-guanosine in rat meninges and is useful for studying the mechanism of guanosine receptors and purine metabolism.
- Useful for studying guanosine receptors
- Used in research on purine metabolism
- Interacts via hydrogen bonding with human purine nucleoside phosphorylase
Cambridge Isotope Laboratories Uridine diphosphate-Alpha-D-glucose NH4 salt (glucose-1 2 3 4 5 6 -13C6 99%) in solution CP 95% 100 umol
Uridine diphosphate-Alpha-D-glucose NH4 salt (glucose-1 2 3 4 5 6 -13C6 99%) in solution CP 95% 100 umol
Medchemexpress LLC 3′-Deoxyguanosine | 3608-58-0 | 97.0% | 267.25 | 10 MG
3′-Deoxyguanosine is a derivative of Guanosine that interacts with human purine nucleoside phosphorylase through hydrogen bonding. It demonstrates moderate displacement activity for [3H]-guanosine in rat meninges. This product is for research use only and not sold to patients.
- Derivative of guanosine
- Interacts with human purine nucleoside phosphorylase
- Useful for studying guanosine receptors
- Useful for studying purine metabolism
- Exhibits moderate displacement activity for [3H]-guanosine in rat meninges
Medchemexpress LLC Aminohippurate (sodium) | 94-16-6 | 99.9% | C9H9N2NaO3 | 1 ML
Aminohippurate sodium is a diagnostic agent primarily used in medical tests for measuring renal plasma flow. This product is intended for laboratory research and is not validated for medical applications.
- Used for renal plasma flow measurement
- For research use only
- Purity of 99.9%
- Supplied as a 10 mM, 1 mL solution in DMSO
- Stable under recommended storage conditions
Selleck Chemical LLC 2 3 -Dideoxyadenosine
2 3 -Dideoxyadenosine (ddA ddAdo) is an anti-human immunodeficiency virus agent against human immunodeficiency virus (HIV) and human hepatitis B virus (HBV) replication