Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Reference and calibration standards for environmental testing protocols; includes water, wastewater, EPA, TOC, DOD and other laboratory and environmental chemical standards.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Naproxen sodium (CAS 26159-34-2) is a non-selective cyclooxygenase (COX) inhibitor that suppresses both COX-1 and COX-2 activity In vitro it exhibits IC50 values of 35 48 mol/L for COX-1 and 64 62 mol/L for COX-2 Naproxen sodium influences satellite cell biology by affecting proliferation fusion and differentiation particularly when both COX-1 and COX-2 are inhibited In HCA-7 colon cancer cells naproxen reduces cell viability with an IC50 of 1 45 0 07 M after 48-hour exposure Clinically repeated dosing in volunteers results in substantial inhibition of COX isoforms while research in menstrual migraine models shows significant reductions in headache parameters
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Fuchsine base monohydrochloride (632-99-5) is a synthetic dye belonging to the triphenylmethane family It is designed for staining applications to visualize cellular and tissue components in histological and cytological studies Fuchsine base monohydrochloride exerts its biological activity primarily through binding with negatively charged groups particularly carboxyl-rich sites within cell structures Based on these properties Fuchsine base monohydrochloride holds research potential in biomedical cytological and histological applications for the analysis of tissue morphology cellular anatomy and biological process visualization
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Trimethoprim (CAS 738-70-5) is a small-molecule inhibitor targeting bacterial dihydrofolate reductase (DHFR) It is designed to selectively inhibit DHFR thereby disrupting folate metabolism and nucleic acid synthesis in bacteria Trimethoprim exerts its biological activity primarily through competitive inhibition of bacterial DHFR In experimental studies trimethoprim demonstrates inhibitory activity with IC50 values ranging from approximately 5 to 15 nM against bacterial DHFR enzymes Based on these pharmacological properties trimethoprim holds research potential in studies of microbiology urinary tract infections bacterial metabolism folate biosynthesis antimicrobial resistance and in the pharmacological profiling of antibacterial agents
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Sulfadoxine (CAS 2447-57-6) is a small-molecule inhibitor targeting dihydropteroate synthase It is designed to competitively inhibit this enzyme thereby disrupting folate biosynthesis in Plasmodium parasites Sulfadoxine exerts its biological activity primarily through inhibition of dihydropteroate synthase mediated folate synthesis In cell-based studies sulfadoxine demonstrates inhibitory activity against human immunodeficiency virus (HIV) replication within peripheral blood mononuclear cells (PBMCs) with an IC50 value in the micromolar range Based on these pharmacological properties sulfadoxine holds research potential in antimalarial drug investigation parasite metabolic pathway studies pathogen susceptibility assays antiviral pharmacological experiments and investigations of host-pathogen interactions and viral replication mechanisms
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Cys modifier 1 is a cysteine-selective protein modifier utilized for protein bioconjugation. It is a fluorescent carbonylacrylic derivative that bears nitrobenzofurazan (λex=465nm and λem=539 nm).
Cysteine-selective protein modification
Fluorescent carbonylacrylic derivative
Bears nitrobenzofurazan for fluorescence (λex=465nm and λem=539 nm)
Target: Fluorescent dye
Pathway: Others
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool<|a>
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
( )-Baclofen (CAS 1134-47-0) is a selective agonist of the -aminobutyric acid type B (GABAB) receptor a G protein-coupled receptor involved in inhibitory neurotransmission Exhibiting an IC50 of 200 nM ( )-baclofen induces skeletal muscle relaxation and reduces spasticity by activating GABAB-mediated signaling pathways In cellular studies ( )-baclofen inhibits the proliferation of human hepatocellular carcinoma (HCC) cells in a dose-dependent manner induces G0/G1 cell cycle arrest and modulates intracellular cAMP and p21WAF1 expression In vivo it suppresses tumor growth in HCC xenograft models without evident toxicity ( )-Baclofen is thus valuable for investigating GABAB-mediated mechanisms in cancer and neuropharmacology
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More