Organometallic Compounds
Medchemexpress LLC Bromoacetamido-PEG3-azide | 940005-81-2 | ≥97.0% | C10H19BrN4O4 | 100 MG
Bromoacetamido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Contains an Azide group.
- Engages in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups.
- Can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Medchemexpress LLC Tos-PEG3 | 77544-68-4 | 97.0% | 304.36 | 10 G
Tos-PEG3 is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It can also be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
- Utilized in the synthesis of PROTACs.
- Can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports.
Medchemexpress LLC Azido-PEG3-SSPy | 98.6% | 344.45 g·mol⁻¹ | C13H20N4O3S2 | 100 MG
Azido-PEG3-SSPy is a cleavable three-unit polyethylene glycol (PEG3) linker used for assembling antibody-drug conjugates (ADCs) and general bioconjugation. It contains an azide functional group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is compatible with strain-promoted azide-alkyne cycloaddition (SPAAC) with DBCO or BCN partners.
- Cleavable disulfide linker for controlled release.
- Azide-functionalized for CuAAC click chemistry.
- Compatible with SPAAC (DBCO and BCN) reactions.
- High purity suitable for conjugation workflows.
- Multiple pack sizes available for research use.
Medchemexpress LLC Bromoacetamido-PEG3-NH-Boc | 1421933-39-2 | ≥98.0% | C15H29BrN2O6 | 1 G
Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs feature two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based linker
- Utilized in the synthesis of PROTACs
- Connects ligands for E3 ubiquitin ligase and target proteins
- Enables selective degradation of target proteins
- Molecular weight: 413.30
Medchemexpress LLC Azido-PEG3-C6-Cl | 1625717-44-3 | MFCD34471373 | 95.3% | C12H24ClN3O3 | 10MG
Azido-PEG3-C6-Cl is a PEG-based PROTAC linker and click-chemistry reagent containing an azide functional group. It has molecular formula C12H24ClN3O3, molecular weight 293.79 g/mol, and reported purity 95.3%. The product is a colorless to light-yellow liquid supplied in small milligram pack sizes for research use and is stored at -20°C in pure form (stable up to 3 years).
- Acts as a PEG-based linker for PROTAC and conjugate synthesis.
- Contains an azide group compatible with CuAAC and strain-promoted click reactions.
- Reported purity of 95.3% suitable for research applications.
- Available in small pack sizes for synthetic and screening workflows.
- Stable when stored at recommended temperatures, enabling longer-term storage.
TARGETMOL CHEMICALS INC SX-682 10MG
Also available in 1 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SX-682 is a potent selective and orally bioavailable inhibitor of CXCR1/2 has the potential to treat castration-resistant prostate cancer. purity: 99%
Medchemexpress LLC Dbco-PEG3-VC-Exatecan | 2754384-70-6 | 96.7% | 1331.44 g/mol | C71H79FN10O15 | 10 MG
DBCO-PEG3-VC-Exatecan is a drug-linker conjugate used in antibody-drug conjugate (ADC) research that couples a DBCO-functionalized PEG3 valine-citrulline cleavable linker to the topoisomerase I inhibitor exatecan.
- Provides a cleavable valine-citrulline (VC) linker for intracellular release.
- Includes a DBCO handle for strain-promoted azide-alkyne cycloaddition (click chemistry).
- Incorporates a PEG3 spacer to improve solubility and linker flexibility.
- Delivers exatecan, a DNA topoisomerase I inhibitor payload.
- High purity (~96.7%) and large molecular weight (~1331.44 g/mol).
- Soluble in DMSO at 50 mg/mL with ultrasonic assistance.
- Stored sealed at -20 °C; in solution, stable at -80 °C for 6 months and -20 °C for 1 month.
Medchemexpress LLC 1-Propanamine, 3,3'-[oxybis(2,1-ethanediyloxy)]bis- | 4246-51-9 | >99.9% | 100 G
Bis-NH2-C1-PEG3, also known as PROTAC Linker 24, is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade specific target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Appearance: colorless to light yellow liquid
- Molecular formula: C10H24N2O3
- Molecular weight: 220.31
- Storage: 4°C, protect from light. In solvent: -80°C, 6 months; -20°C, 1 month (protect from light)
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 50 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It can be used in the synthesis of the PROTAC SGK3 degrader-1, a potent SKG3 degrader based on PROTAC.
- Polyethylene glycol (PEG)-based PROTAC linker
- Used in synthesis of PROTAC SGK3 degrader-1
- Potent SKG3 degrader
- Related to cancer research
- Related to cancer targeted therapy
Medchemexpress LLC Ms-PEG5-t-butyl ester | 870487-48-2 | MFCD20926382 | 95.0% | C16H32O9S | 10MG
Ms-PEG5-t-butyl ester is a PEG-based linker featuring a t-butyl-protected carboxyl group, designed for use in the chemical synthesis of PROTAC molecules. It provides a hydrophilic spacer to connect ligands while masking the carboxylate during multi-step syntheses.
- Provides a hydrophilic polyethylene glycol spacer to improve solubility.
- Contains a t-butyl-protected carboxyl group for orthogonal protection during synthesis.
- Compatible with standard coupling and deprotection chemistries used in medicinal chemistry.
- Facilitates assembly of bifunctional degraders by spacing ligands and reducing steric hindrance.
- Available in small-scale quantities suitable for research and discovery workflows.
- Reported high purity suitable for synthetic applications; verify with certificate of analysis.
Medchemexpress LLC Nh2-peg5-c6-cl hydrochloride | 2241669-16-7 | 98.0% | 5 G
NH2-PEG5-C6-Cl hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC Calcein (tetraethyl ester) | 1170856-93-5 | 99.5% | 100 MG
Calcein tetraethyl ester is a fluorescent dye used in biology for testing cell viability and short-term cell labeling. It can be transported through the cellular membrane into live cells.
- Molecular weight: 734.75
- Formula: C38H42N2O13
- Appearance: Solid
- Color: Light yellow to yellow
- Emission (Em): 515
- Excitation (Ex): 489
- Solubility in DMSO: 25 mg/mL
- Insolubility in H2O: < 0.1 mg/mL
Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 5 G
THP-PEG3-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Can be used in the synthesis of PROTACs
- Contains two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for the target protein
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC THP-PEG3-OH | 60221-37-6 | 98.7% | 1 G
THP-PEG3-OH is a PEG-based PROTAC linker used in the synthesis of PROTACs. This compound is intended for research use only and is not sold to patients.
- Enables the synthesis of PROTACs
- Functions as a PROTAC linker
- Utilizes the PROTAC pathway
- Facilitates selective degradation of target proteins via the ubiquitin-proteasome system
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 TFA (cereblon ligand-linker conjugates 5 TFA) | 2414913-97-4 | 99.0% | 500 MG
Pomalidomide-PEG3-C2-NH2 TFA is a synthetic E3 ligase ligand-linker conjugate. It is composed of a pomalidomide-based cereblon ligand and a 3-unit PEG linker.
- Comprises a pomalidomide-based cereblon ligand.
- Includes a 3-unit PEG linker.
- Can be used for the synthesis of PROTACs.