Organometallic Compounds
Apexbio Technology LLC Epidermal Growth Factor Receptor Peptide (985-996) 96249-43-3 10mg
Epidermal Growth Factor Receptor Peptide (985-996) (CAS 96249-43-3) corresponds to a C-terminal segment of the EGFR protein involved in receptor autophosphorylation EGFR a transmembrane receptor tyrosine kinase undergoes activation upon ligand binding triggering receptor dimerization and subsequent phosphorylation of specific tyrosine residues within its C-terminus including the 985-996 region This phosphorylation facilitates recruitment of SH2 domain-containing signaling proteins thereby initiating pathways such as MAPK Akt and JNK which regulate cell proliferation migration and adhesion This peptide serves as a useful research tool for elucidating EGFR-mediated signaling and studying kinase-substrate interactions in cellular models
eMolecules Oakwood Chemical Sodium bis (trimethylsilyl) amide 1M in THF 3kg 629469699 S14981 0 000 1070-89-9 MFCD00009835 183 377 C6H18NNaSi2
Oakwood Chemical Sodium bis (trimethylsilyl) amide 1M in THF 3kg 629469699 S14981 0 000 1070-89-9 MFCD00009835 183 377 C6H18NNaSi2
![eMolecules {3-[(tert-butyldimethylsilyl)oxy]cyclobutyl}methanol | 1394119-83-5 | MFCD23106334 | 1g](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502159558.JPG-250.jpg)
eMolecules {3-[(tert-butyldimethylsilyl)oxy]cyclobutyl}methanol | 1394119-83-5 | MFCD23106334 | 1g
Pharmablock | {3-[(tert-butyldimethylsilyl)oxy]cyclobutyl}methanol | 1g | 551073908 | PB05119 | | 1394119-83-5 | MFCD23106334 | 216.396 | C11H24O2Si
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Medchemexpress LLC GSK2807 trifluoroacetate | 2245255-66-5 | 99.8% | 566.53 | C21H33F3N8O7 | 100 MG
GSK2807 trifluoroacetate is a SAM-competitive small-molecule inhibitor of the histone methyltransferase SMYD3, reported with Ki = 14 nM and IC50 = 130 nM. It is provided as the trifluoroacetate salt for research use in biochemical and cell-based studies of methylation-dependent signaling.
- High potency against SMYD3 (Ki = 14 nM; IC50 = 130 nM).
- SAM-competitive mechanism of action.
- Supplied as trifluoroacetate (TFA) salt.
- High chemical purity (>99.8%).
- Molecular weight 566.53 g/mol.
- Suitable for biochemical and cell-based assay development.
eMolecules 3-(t-Butyldimethylsilyloxy)-4-chloro-2-fluorophenylboronic acid | 1256354-94-5 | MFCD17015761 | 1g
Combi-Blocks | 3-(t-Butyldimethylsilyloxy)-4-chloro-2-fluorophenylboronic acid | 1g | 117524740 | BB-6525 | 95.000 | 1256354-94-5 | MFCD17015761 | 304.620 | C12H19BClFO3Si
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Apexbio Technology LLC Ribosomal protein L3 peptide (202-222) amide 5mg
Ribosomal protein L3 peptide (202-222) amide is a synthetic peptide corresponding to residues 202 to 222 of ribosomal protein L3 with the sequence Met-Ser-His-Arg-Lys-Tyr-Glu-Ala-Pro-Arg-His-Gly-His-Leu-Gly-Phe-Leu-Pro-Arg-Lys-Arg-amide and a molecular formula of C114H182N42O25S (Mw 2573) Ribosomal protein L3 is an integral component of the large ribosomal subunit (60S) interacting with 23S rRNA to constitute the ribosome s peptidyl transferase center This particular peptide segment can bind to HIV-1 TAR RNA suggesting its role in studying TAR-mediated transcriptional activation and RNA-protein interactions in molecular virology research
Apexbio Technology LLC OSI-930 728033-96-3 25mg
OSI-930 (CAS 728033-96-3) is a small molecule inhibitor targeting multiple receptor tyrosine kinases including Flt1 (IC 8 nM) KDR/VEGFR2 (IC 9 nM) CSF-1R (IC 15 nM) Lck c-Raf and Kit (IC 80 nM) In cellular studies OSI-930 inhibits proliferation and induces apoptosis in HMC-1 cells whose survival is dependent on Kit signaling while exhibiting minimal effects on COLO-205 cells under standard conditions Additionally OSI-930 inactivates cytochrome P450 3A4 in a time- and concentration-dependent manner and alters its spectral properties These characteristics make OSI-930 a valuable tool compound for investigating receptor tyrosine kinase signaling pathways and related cellular processes in cancer research
Apexbio Technology LLC Epidermal growth factor receptor (994-1002) acetyl/amide 10mg
Epidermal growth factor receptor 994-1002 acetyl amide is a peptide fragment derived from the epidermal growth factor receptor (EGFR) acetylated and amidated at its termini It is designed to serve as a tool for investigating receptor-ligand interactions and receptor activation mechanisms associated with EGFR-mediated signaling pathways Epidermal growth factor receptor 994-1002 acetyl amide acts by enabling the study of EGFR activation particularly receptor dimerization and autophosphorylation processes Based on its biological characteristics this peptide has research potential in evaluating therapeutic strategies targeting EGFR-mediated oncogenesis including studies of proliferation differentiation migration and survival in malignancies such as glioblastoma and lung cancers
Medchemexpress LLC Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH | 2351103-63-2 | 93.9% | 10 MG
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. It is for research use only.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Linker used in PROTAC technology
- Targets Cereblon
- For research use only
Medchemexpress LLC NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 250 MG
NH-bis(C2-PEG2-NH-Boc) | 2182601-69-8 | 250 MG
Cayman Chemical Tubastatin A trifluoroacetat
Potent HDAC6 inhibitor (IC50 = 15 nM) with 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM); induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures; displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM