Solvents
Various organic solvents suitable for industrial, analytical, educational, medical, and research applications, including chromatography, chemical and organic syntheses, and purification processes. Products, including an extensive line of water products, an essential solvent for any laboratory, are available in a range of chemical compositions, quantities, purity levels, and reagent grades, and are curated to optimize your workflows.
Sigma Aldrich Boron Trifluoride-Methanol Solution
MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.
Potassium Tetrakis(4-chlorophenyl)borate 98.0+%, TCI America™
CAS: 14680-77-4 Molecular Formula: C24H16BCl4K Molecular Weight (g/mol): 496.10 MDL Number: MFCD00043105 InChI Key: VHPYLDPFVZBNQT-UHFFFAOYSA-N Synonym: potassium tetrakis 4-chlorophenyl borate,tetrakis 4-chlorophenyl boron potassium,k-tcpb,potassium tetrakis 4-chlorophenyl boranuide,potassium tetrakis 4-chlorophenyl borate, selectophore tm PubChem CID: 23679691 IUPAC Name: boron(3+) potassium tetrakis(3-chlorobenzen-1-ide) SMILES: [B+3].[K+].ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1
2,6-Dimethylphenylboronic Acid (contains varying amounts of Anhydride) 98.0+%, TCI America™
CAS: 100379-00-8 Molecular Formula: C8H11BO2 Molecular Weight (g/mol): 149.98 MDL Number: MFCD01009693 InChI Key: ZXDTWWZIHJEZOG-UHFFFAOYSA-N Synonym: 2,6-dimethylphenyl boronic acid,2,6-dimethylbenzeneboronic acid,2,6-dimethylphenyl boranediol,2,6-dimethylboronic acid,m-xylene-2-boronic acid,2,6-dimethyl-phenylboronic acid,boronic acid, 2,6-dimethylphenyl,2-borono-m-xylene,pubchem16357,acmc-1c3za PubChem CID: 583322 IUPAC Name: (2,6-dimethylphenyl)boronic acid SMILES: CC1=CC=CC(C)=C1B(O)O
Potassium tetrakis(4-chlorophenyl)borate, 98%
CAS: 14680-77-4 Molecular Formula: C24H16BCl4K Molecular Weight (g/mol): 496.10 MDL Number: MFCD00043105 InChI Key: VHPYLDPFVZBNQT-UHFFFAOYSA-N Synonym: potassium tetrakis 4-chlorophenyl borate,tetrakis 4-chlorophenyl boron potassium,k-tcpb,potassium tetrakis 4-chlorophenyl boranuide,potassium tetrakis 4-chlorophenyl borate, selectophore tm PubChem CID: 23679691 IUPAC Name: potassium;tetrakis(4-chlorophenyl)boranuide SMILES: [B+3].[K+].ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1.ClC1=CC=C[C-]=C1
eMolecules Ambeed / (4-Chlorophenyl)boronic acid / 1g / 490515262 / A153651 / / 1679-18-1 / MFCD00039137 / 156.370 / C6H6BClO2
Ambeed / (4-Chlorophenyl)boronic acid / 1g / 490515262 / A153651 / / 1679-18-1 / MFCD00039137 / 156.370 / C6H6BClO2
Chemscene ChemScene | (5-Bromo-2-chlorophenyl)boronic acid | 250MG | CS-0175198 | 0.98 | 774608-50-3| MFCD12026740 | 235.27
ChemScene | (5-Bromo-2-chlorophenyl)boronic acid | 250MG | CS-0175198 | 0.98 | 774608-50-3| MFCD12026740 | 235.27
Medchemexpress LLC 2-((5-((4-fluorophenyl)carbamoyl)pyrimidinyl)sulfanylmethyl)-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 98.7% | 25 MG
SX-682 (CAS 1648843-04-2) is an orally bioavailable small-molecule allosteric inhibitor of CXCR1 and CXCR2 investigated for oncology research. It blocks recruitment of immunosuppressive myeloid-derived suppressor cells to the tumor microenvironment and can enhance the activity of checkpoint inhibitors.
- Oral bioavailability and potent CXCR1/2 antagonism
- Useful for preclinical and clinical oncology research
- Blocks myeloid-derived suppressor cell recruitment to tumors
- Well-characterized chemical identity: CAS 1648843-04-2, C19H14BF4N3O4S
- Analytical purity typically >98% and supplied as a 25 MG vial
![Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000234135.png-250.jpg)
Medchemexpress LLC 2-[[5-[(4-fluorophenyl)carbamoyl]pyrimidin-2-yl]sulfanylmethyl]-4-(trifluoromethoxy)phenyl boronic acid | 1648843-04-2 | 99.7% | 10 MG
SX-682 is an orally bioavailable small-molecule allosteric inhibitor of chemokine receptors CXCR1 and CXCR2 under clinical investigation for oncology indications; it blocks recruitment of myeloid-derived suppressor cells and can enhance T-cell activity.
- Orally bioavailable small-molecule CXCR1/2 inhibitor
- Blocks recruitment of myeloid-derived suppressor cells (MDSCs)
- Enhances T-cell activation and antitumor immune responses
- Demonstrated activity in preclinical tumor models and clinical trials
- Supplied with high purity (typical >99%) and available in small-mass packaging for research
Apexbio Technology LLC CEP-18770 847499-27-8 10mM (in 1mL DMSO)
CEP-18770 (CAS 847499-27-8) is a reversible boronic acid-based inhibitor of proteasome chymotrypsin-like activity It specifically targets the proteasome s P2 threonine protease subunit reducing NF- B signaling and the expression of downstream effectors With a reported IC50 of 3 8 nM CEP-18770 induces apoptosis in multiple myeloma cell lines and inhibits osteoclastogenesis and angiogenesis via suppression of RANKL signaling Research supports its potential use in oncology particularly for multiple myeloma showing selective cytotoxicity sparing normal epithelial and bone marrow-derived cells
Apexbio Technology LLC Bortezomib (PS-341) 179324-69-7 10mM (in 1mL DMSO)
Bortezomib (PS-341 CAS number 179324-69-7) is a reversible proteasome inhibitor structurally composed as an N-terminally protected dipeptide (Pyz-Phe-boroLeu) containing pyrazinoic acid phenylalanine and leucine with boronic acid substitution It exerts biological activity primarily by inhibiting proteasomal degradation pathways thereby accumulating pro-apoptotic factors and initiating programmed cell death Bortezomib inhibits proliferation in cell-based assays such as human non-small cell lung cancer H460 cells (IC50 0 1 M) It has clinical approval for relapsed multiple myeloma and mantle cell lymphoma and is widely employed in research to study proteasome-regulated cellular processes and apoptosis signaling pathways
Apexbio Technology LLC MLN2238(Synonyms: Ixazomib, MLN-2238, Ninlaro, MLN9708, Ixazomib citrate), 10mM (in 1mL DMSO), CAS: 1072833-77-2.
MLN2238 (CAS number 1072833-77-2) is a dipeptidyl boronic acid derivative designed as a reversible inhibitor of the 5 subunit (chymotrypsin-like activity) of the 20S proteasome with reported IC50 and Ki values of 3 4 nM and 0 93 nM respectively At higher concentrations MLN2238 also targets the proteasome s 1 (caspase-like) and 2 (trypsin-like) subunits In preclinical studies using xenograft and genetically-engineered models of hematologic malignancies MLN2238 exhibited potent antitumor activity promoting apoptosis and suppressing pathways such as NF- B MLN2238 has research applications in oncology particularly against multiple myeloma and lymphoma including in bortezomib-resistant cell lines