Polyphyllin D (CAS 55916-51-3) is a bioactive steroidal saponin isolated from the plant Paris yunnanensis Franch It exhibits significant anticancer activity primarily through induction of apoptosis cell-cycle arrest and inhibition of cell migration and invasion Studies suggest Polyphyllin D mediates its effects via modulation of signaling pathways including PI3K/Akt NF- B and MAPK cascades Due to these mechanistic insights Polyphyllin D serves as a valuable research tool for investigating molecular pathways associated with tumorigenesis and metastatic progression