Sugar acids and derivatives
Medchemexpress LLC 4-methylumbelliferyl α-L-iduronide | 66966-09-4 | MFCD00135894 | ≥99.0% | 352.29 g/mol | C16H16O9 | 500 UG
4-Methylumbelliferyl α-L-iduronide is a fluorogenic reagent used as a sensitive substrate for α-L-iduronidase and related lysosomal enzyme assays. Enzymatic hydrolysis releases 4-methylumbelliferone, permitting fluorescence-based detection and quantitation in biochemical and cell-based assays.
- Fluorogenic substrate for α-L-iduronidase assays.
- Enables sensitive fluorescence detection and quantitation.
- High purity (≥99.0%) suitable for biochemical applications.
- Available in small research quantities (for example, 500 μg) for assay development.
- Stable solid form for convenient storage and handling.
AdipoGen N-Z-L-Homoserine lactone
Chemical. CAS 35677-89-5. Formula C12H13NO4. MW 235.24. N-Z-L-Homoserine lactone is a synthetic building block or intermediate used in the synthesis of biological active agents and analogs of bacterial quorum-sensing signaling molecules. N-Z-L-Homoserine lactone is shown to irreversibly inactivate the 3C cysteine proteinase of hepatitis A virus HAV and might be a scaffold for potent cyteine protein inhibtiors. Shown to reduce the lag phase duration LPD and increase the exponential growth rate EGR of three strains of Pseudomonas fluorescens isolated from refrigerated raw milk.
Medchemexpress LLC D-KLVFFA | 342877-55-8 | 99.3% | 723.90 | 25 MG
D-KLVFFA is an inhibitor of Amyloid-β assembly, with an IC50 of 2.6 μM, that can be used in Alzheimer's disease studies.
- Inhibitor of Amyloid-β assembly
- IC50 of 2.6 μM
- Used in Alzheimer's disease studies
- Molecular formula: C38H57N7O7
- Molecular weight: 723.90
- Sequence: D-Lys-D-Leu-D-Val-D-Phe-D-Phe-D-Ala
- Appearance: White to off-white solid
Medchemexpress LLC 4-Methylumbelliferyl-α-D-Glucopyranoside | 17833-43-1 | 99.99% | 338.31 | 25 MG
4-Methylumbelliferyl-α-D-Glucopyranoside is a fluorescent substrate for α-glucosidase, which releases the fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage. 4-MU exhibits pH-dependent fluorescence excitation activity, with excitation wavelengths of 320 nm at low pH (1.97-6.72) and 360 nm at high pH (7.12-10.3). The emission wavelength of 4-Methylumbelliferyl-α-D-Glucopyranoside increases with decreasing pH, ranging from 445-455 nm. This compound can be utilized as a biomarker for Fabry and Pompe diseases to quantify α-glucosidase activity in infant blood spot samples.
- Fluorescent substrate for α-glucosidase.
- Releases fluorescent moiety 4-methylumbelliferyl (4-MU) upon cleavage.
- 4-MU has pH-dependent fluorescence excitation activity.
- Can be used as a biomarker for Fabry and Pompe diseases.
- Quantifies α-glucosidase activity in infant blood spot samples.
Medchemexpress LLC Integrin alpha V beta 3 protein, mouse (HEK293, His) | >95.0% | 50UG
Integrin alpha V beta 3 protein, mouse (HEK293, His) is a recombinant heterodimeric integrin complex produced in HEK293 cells and supplied with a C-terminal His tag. It is intended for research use to support studies of integrin-mediated cell adhesion, signaling, and ligand interactions.
- Recombinant heterodimeric integrin complex (ITGAV:ITGB3).
- Expressed in HEK293 mammalian cells.
- C-terminal His tag for detection and purification.
- Purity greater than 95% as determined by reducing Tris-Bis PAGE.
- Observed molecular weight 90-130 kDa.
- Available in small-scale sizes suitable for biochemical assays (20 μg, 50 μg, 100 μg).
- For research use only; not for therapeutic or diagnostic use.
Medchemexpress LLC (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (Surfagon) | 52435-06-0 | 99.5% | 1167.32 | 10 MG
(Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH, also known as Surfagon, is an agonist of gonadotropin-releasing hormone (GnRH). It is utilized as an internal standard for the LC-MS analysis of leuprorelide acetate and has potential applications in biochemical analysis and fertility research.
- Agonist of gonadotropin-releasing hormone (GnRH).
- Used as an internal standard for LC-MS analysis of leuprorelide acetate.
- Increases anxiety behavior in adult male rats in vivo.
- Improves fertility in cows and prevents embryo death in vivo.
- Potential applications in biochemical analysis.
- Potential applications in fertility studies.
![Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000286978.png-250.jpg)
Medchemexpress LLC 7-chloro-3-(2,4-dimethoxyphenyl)-5-methyl-thiazolo[4,5-d]pyrimidine-2-thione | 2459916-56-2 | 98.5% | 353.85 g/mol | C14H12ClN3O2S2 | 10 MG
CDK1/Cyc B-IN-1 is a small-molecule inhibitor selective for the CDK1-cyclin B kinase complex. It inhibits CDK1-cyclin B activity (reported IC50 ≈97 nM) and induces G2/M cell-cycle arrest and apoptosis in cancer cell lines. The compound is supplied as a solid with high purity and is used in biochemical and cellular studies of cell-cycle regulation.
- Selective CDK1-cyclin B inhibitor with reported IC50 ≈97 nM.
- Induces G2/M cell-cycle arrest and apoptosis in cell lines.
- Suitable for biochemical kinase assays and cell-based studies.
- High supplied purity for reproducible results.
- Soluble in DMSO at 100 mg/mL; use newly opened DMSO.
- Stable as a powder under recommended cold storage conditions.
eMolecules Ambeed -D-glucuronide-pNP-carbonate 50mg 847281786 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Ambeed -D-glucuronide-pNP-carbonate 50mg 847281786 A1365593 0 000 894095-98-8 913 842 C45H43N3O18
Medchemexpress LLC [D-Trp34]-Neuropeptide Y | 153549-84-9 | 99.7% | 4311.72 | 10 MG
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. It is significantly less potent at the NPY Y1, Y2, Y4, and y6 receptors. This product markedly increases food intake in rats.
- Potent and selective neuropeptide Y (NPY) Y5 receptor agonist.
- Markedly increases food intake in rats.
Medchemexpress LLC Integrin alpha V bet 100ug | 100ug
Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) is a recombinant protein dimer complex containing human-derived Integrin alpha V beta 6 protein expressed by HEK293 with C-His C-Avi labeled tag Integrin alpha V beta 6 Protein Human (HEK293 His-Avi) has molecular weight of 90-150 kDa
Medchemexpress LLC IFN-beta Rhesus Mac 10ug
IFN-beta Protein Rhesus Macaque (HEK293 Fc Solution) is the recombinant rhesus macaque-derived IFN-beta protein expressed by HEK293 with C-mFc tag
Medchemexpress LLC Ethyl glucuronide | 17685-04-0 | 99.2% | 222.19 | 1 ML
Ethyl glucuronide is an endogenous metabolite of ethanol. It serves as a biomarker for ethanol exposure, accumulating in hair and reflecting alcohol intake over time. It is also an agonist for TLR4.
- Endogenous metabolite
- Biomarker for ethanol exposure
- Agonist for TLR4
- Appearance: Solid, white to off-white
- Storage: -20°C, protect from light, stored under nitrogen. In solvent: -80°C for 6 months; -20°C for 1 month (protect from light, stored under nitrogen).
- Useful in research for studying ethanol exposure and its effects
- Can be used to block the formation of the TLR4-MD2 complex and stimulate the expression of TLR4-dependent SEAP protein in HEK-TLR4 cells
- Has been shown to reduce tactile threshold and induce hyperalgesia in Sprague-Dawley rat models
Medchemexpress LLC SN-38 glucuronide (SN-38G) | 121080-63-5 | 99.5% | 568.53 | 10 MG
SN-38 glucuronide is an inactive metabolite of the anticancer active molecule Irinotecan and has toxic effects on the gastrointestinal tract. Irinotecan is a topoisomerase I inhibitor which can be used for researching colon and rectal cancer.
- Inactive metabolite of the anticancer active molecule irinotecan.
- Has toxic effects on the gastrointestinal tract.
- Cells capable of metabolizing SN38 to SN38-G show increased resistance to extracellular SN38.
- Can serve as a substrate for gut microbial β-glucuronidase enzymes, which reactivate SN-38 in the intestine, leading to increased toxic effects on the gut.
