Sugar acids and derivatives
Medchemexpress LLC D-3263 hydrochloride | 1008763-54-9 | MFCD22665741 | 98.0% | 409.95 | C21H32ClN3O3 | 10 MG
D-3263 hydrochloride is an enteric-coated, orally bioavailable agonist of transient receptor potential melastatin member 8 (TRPM8). It binds and activates TRPM8, modulates calcium and sodium flux, and has been investigated for potential antineoplastic effects and modulation of androgen-related pathways.
- Orally bioavailable TRPM8 agonist suitable for in vivo studies.
- Enteric-coated formulation for improved gastrointestinal stability.
- High purity (98.0%) supports reproducible experimental results.
- Soluble in DMSO and formulatable for common in vivo vehicles.
- Stable when stored sealed at 4°C; solvent stability at -80°C for extended storage.
![Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097081.png-250.jpg)
Apexbio Technology LLC heparin cofactor II precursor fragment [Homo sapiens] 5mg
Heparin cofactor II precursor fragment is a thrombin inhibitor peptide targeting human thrombin (factor IIa) It is designed to inhibit thrombin activity thereby modulating blood coagulation pathways Heparin cofactor II precursor fragment exerts its biological activity primarily through serine protease inhibition facilitated in the presence of heparin or dermatan sulfate Based on these pharmacological properties heparin cofactor II precursor fragment holds research potential in investigating thrombin inhibition mechanisms blood coagulation pathways and conditions associated with altered coagulation such as heparin cofactor II deficiency and hypercoagulability disorders
Medchemexpress LLC MAC-545496 | 838810-96-1 | 98.0% | 10 MM * 1 ML
MAC-545496 is a potent nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR), demonstrating strong binding affinity (Kd ≤ 0.1 nM). It acts as an antivirulence agent, effectively reversing β-lactam resistance in Methicillin-resistant Staphylococcus aureus (MRSA) strains, and is intended for research use only.
- Potently synergizes with Cefuroxime and Oxacillin against S. aureus clinical isolates.
- Inhibits mprF expression in a concentration-dependent manner (IC50 of 0.0376 μg/mL).
- Inhibits citrate-induced biofilm formation in wild-type strains.
- Effective as monotherapy for MRSA-infected Galleria mellonella larvae, increasing survival.
Medchemexpress LLC Integrin alpha 5 beta 1 protein, human (biotinylated, HEK293, His-Avi) | 95.0% | 50UG
Biotinylated human integrin alpha 5 beta 1 is a recombinantly produced heterodimer expressed in HEK293 cells and supplied as a lyophilized powder with Avi and 8xHis tags. The protein is glycosylated (approx. 110-140 kDa), of high purity, and formulated with trehalose to preserve activity for binding assays and assay development.
- Lyophilized, stable formulation for long-term storage.
- Biotinylated for immobilization on streptavidin surfaces.
- Expressed in mammalian cells to preserve native glycosylation.
- C-terminal Avi and 8xHis tags for detection and purification.
- High purity as determined by SDS-PAGE (>95%).
- Low endotoxin level (<1 EU/μg) suitable for sensitive assays.
- Provided with certificate of analysis and safety data sheet.
- Reconstitute to at least 100 μg/mL in ddH2O for optimal performance.
Apexbio Technology LLC PKH67 Green Fluorescent Cell Linker Kit(Synonyms: PKH67 Cell Labeling Kit, PKH67 Fluorescent Dye Kit, PKH67 Green Fluorescent Cell Dye), 250T.
PKH67 Green Fluorescent Cell Linker Kit is designed for fluorescent labeling of cell membranes The kit utilizes the green fluorescent probe PKH67 a lipophilic dye that integrates stably into lipid regions of the plasma membrane emitting bright green fluorescence Upon cell division PKH67 distributes evenly among progeny cells causing fluorescence intensity to diminish incrementally with cell proliferation Due to its stability low cytotoxicity and minimal staining of adjacent cells PKH67 is widely applied in vitro and in vivo for tracking cell migration localization and monitoring cell proliferation dynamics Additionally PKH67 can be combined with other fluorescent dyes such as PKH26 for multiplex cell-labeling studies
Medchemexpress LLC Lucifer Yellow CH dipotassium salt | 71206-95-6 | MFCD00013445 | 99.8% | 521.57 | C13H9K2N5O9S2 | 10 MG
Lucifer Yellow CH dipotassium salt is a high-intensity fluorescent tracer used in neuroscience and cell biology for intracellular labeling, neuronal tracing, gap junction analysis, and selective cell visualization. Supplied as the dipotassium salt with high reported purity, it is suitable for fluorescence microscopy and experiments requiring reliable, fixable fluorescent markers.
- High-intensity fluorescence for sensitive detection.
- Useful for neuronal tracing and monitoring neuronal branching.
- Enables gap junction detection and characterization.
- Reactive hydrazyl groups allow fixation and labeling with aldehyde-based methods.
- Suitable for fluorescence microscopy and electrophysiological assays.
AdipoGen 3OH-C10-L-HSL
Chemical. CAS 192883-12-8. Formula C14H25NO4. MW 271.35. Synthetic. N-3-hydroxydecanoyl-L-homoserine lactone is a small diffusible signaling molecule secreted by various bacteria and involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism. This lactone is produced via lactonolysis from 3-oxodecanoyl-homoserine lactone, altering quorum sensing or contributing to quorum quenching. The applications of this molecule include regulation of virulence and exoproteases.
Medchemexpress LLC BSJ-04-122 | 2513289-74-0 | 99.9% | 313.74 g/mol | C15H12ClN5O | 10 MG
BSJ-04-122 is a covalent dual inhibitor of the MAP kinase kinases MKK4 and MKK7 developed for research use. It demonstrates potent enzymatic inhibition (IC50 4 nM for MKK4; 181 nM for MKK7) and is applied in studies of cancer biology and MAPK signaling. The compound is supplied as a solid with high chemical purity and recommended storage conditions for both powder and solution forms.
Apexbio Technology LLC Cyclosporin D 63775-96-2 25mg
Cyclosporin D (CAS 63775-96-2) is a structural analogue of Cyclosporin A with comparatively reduced immunosuppressive activity Mechanistically it weakly inhibits lymphocyte proliferation induced by mitogens such as PHA PWM PMA and Ca 2 and suppresses Ca 2 /calmodulin-dependent phosphorylation of elongation factor 2 (EF-2) in mouse pancreatic cells In preclinical models Cyclosporin D overcomes Adriamycin resistance in multidrug-resistant ovarian cancer cells and inhibits TPA-induced ear edema and alkaline phosphatase activity in mice Additionally it displays inhibitory effects on the growth of malarial parasites both in vitro and in vivo Cyclosporin D serves as a standard in Cyclosporin A quantification and as a research tool in immunology oncology and antiparasitic studies
Medchemexpress LLC 4-Methylumbelliferyl phosphate | 3368-04-5 | 99.8% | 256.15 | 1 ML
4-Methylumbelliferyl phosphate (4-MUP) is an anionic organophosphate and a fluorogenic substrate for both acid and alkaline phosphatase. It is also recognized as a nerve agent simulant, primarily for research use.
- Anionic organophosphate
- Fluorogenic substrate for acid and alkaline phosphatase
- Nerve agent simulant
- Used in serum acid phosphatase assays
Medchemexpress LLC Dodecanedioic acid-d4 | 97543-02-7 | 234.33 | 10 MG
Dodecanedioic acid-d4 is the deuterium labeled version of Dodecanedioic acid. Dodecanedioic acid is an orally active straight-chain dicarboxylic acid that acts as an alternative energy substrate. It can be rapidly oxidized during exercise, reducing muscle fatigue without stimulating insulin secretion, and also exhibits blood glucose-lowering activity in non-insulin-dependent diabetes mellitus.
- Deuterium labeled compound for quantitative tracing during drug development.
- Reduces muscle fatigue during exercise.
- Exhibits blood glucose-lowering activity.
![Alkali Scientific MUG [4 Methylumbelliferyl β D glucuronide Trihydrate], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000661658.jpg-250.jpg)
Alkali Scientific MUG [4 Methylumbelliferyl β D glucuronide Trihydrate], 1 G
Methylumbelliferyl β-D Glucuronide Trihydrate, 1 g is a highly sensitive biochemical reagent used in the detection and study of glucuronidase enzyme activity. The substrate is hydrolyzed by glucuronidases to produce a fluorescent product that can be quantified, making it valuable for enzyme assays in biochemical research. It is used in clinical diagnostics, microbiological testing, and enzyme kinetics studies to measure glucuronidase activity. The high purity and sensitivity of this reagent make it suitable for detecting low enzyme concentrations, ensuring precise and reproducible results in applications that require accurate enzyme activity quantification.
Alkali Scientific Leupeptin Hemisulfate, 1 Milligram
Leupeptin Hemisulfate is a potent protease inhibitor available in a 1-milligram quantity. It is primarily used in biochemical research to inhibit serine, cysteine, and threonine proteases. Leupeptin is commonly employed to prevent proteolysis in experiments involving protein isolation, enzyme assays, and cell culture studies. By inhibiting a wide range of proteases, Leupeptin preserves the integrity of proteins during their extraction and purification processes. This reagent is essential for studies focusing on enzyme activity, protein-protein interactions, and various cellular mechanisms in both in vitro and in vivo research applications.