Glycerolipids
Medchemexpress LLC 1H-Indole-2-carbonitrile, 6-hydroxy-1-(1H-pyrazol-4-ylmethyl)-5-[[4-[[6-(2,2,2-trifluor... | 1857417-10-7 | 98.2% | 566.60 | 1 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. It is for research use only and not sold to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity towards MLL fusion protein transformed cells.
- Binds to menin with a Kd of 6.5 nM.
- Leads to strong down-regulation of Hoxa9 and Meis1 gene expression.
- Reduces tumor volume in mice xenografts.
- Improved exposure and Cmax in blood plasma.
- Low clearance and a half-life of about 1.6 hours.
- High oral bioavailability (~50%).
- Soluble in DMSO.
- Soluble in various in vivo protocols, including 10% DMSO, 40% PEG300, 5% Tween-80, 45% Saline.
Medchemexpress LLC Tributyrin (glyceryl tributyrate) | 60-01-5 | 98.91% | 302.36 | 5 ML
Tributyrin (Glyceryl tributyrate) is a neutral short-chain fatty acid triglyceride that serves as a stable and rapidly absorbed proagent of Butyric Acid. It diffuses through biological membranes and is metabolized by intracellular lipases, which releases effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic, and differentiation-inducing effects.
- Enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells.
- Induces differentiation, growth arrest, and apoptosis in androgen-sensitive and androgen-resistant human prostate cancer cell lines.
- Attenuates metabolic and inflammatory changes associated with obesity through a GPR109A-dependent mechanism.
- Alleviates gut microbiota dysbiosis to repair intestinal damage in antibiotic-treated mice.
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.2% | 566.60 | 50 MG
MI-538 | 1857417-10-7 | 98.2% | 566.60 | 50 MG
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.0% | 566.60 | 25 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. For research use only. We do not sell to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity toward MLL fusion protein transformed cells, with no effect (up to 6 μM) on control cell lines HL-60 and HM-2 that do not harbor MLL translocations.
- Binds to menin with low nanomolar affinity (Kd=6.5 nM).
- Potent cellular activity due to improved binding affinity to menin and possibly increased cell membrane permeability.
- Results in strong down-regulation of Hoxa9 and Meis1 gene expression.
- In vivo, it causes an approximately 80% reduction in MV4;11 tumor volume without significant toxicity.
- Demonstrates improved exposure (AUC values), Cmax, and lowest clearance in blood plasma.
- Has a half-life of about 1.6 h and high oral bioavailability (~50%).
Selleck Chemical LLC Triolein S3590-25mg
Triolein is an inhibitor of metalloproteinase-1 (MMP-1) and reduces both the expression of IL-6 and ROS generation in irradiated keratinocytes
Medchemexpress LLC Triacetin | 102-76-1 | 99.6% | 1 ML
Triacetin (Glyceryl triacetate) is a synthetic, orally active compound that increases acetate bioavailability in glioma cells. It induces glioma cell growth arrest and apoptosis, freely crossing the blood brain barrier/plasma membrane. This compound also increases histone acetylation and enhances the chemotherapeutic efficacy of Temozolomide. It is intended for research use only.
- Induces growth arrest in various glioma cells
- Inhibits U87MG cell viability
- Induces apoptosis in GBM cancer cells
- Decreases class I and II HDAC mRNA expression
- Inhibits HDAC-8 activity
- Activates mTOR complexes downstream genes
- Increases tumor suppressor miRs
- Enhances chemotherapeutic efficacy with Temozolomide
- Increases survival in animal models with GBM-derived GSCs
Medchemexpress LLC 1,3-glyceryl dilinoleate | 15818-46-9 | MFCD00056310 | ≥95.0% | 616.95 g·mol⁻¹ | C39H68O5 | 25 MG
1,3-Glyceryl dilinoleate is an unsaturated diacylglycerol used as a research reagent in lipid chemistry and biochemical studies. It has chemical formula C39H68O5 and a molecular weight of 616.95 g·mol⁻¹, and is commonly supplied in small-mass packages for laboratory use.
- Used as a reagent in lipid and membrane research.
- Chemical formula C39H68O5 and molecular weight 616.95 g·mol⁻¹.
- CAS number 15818-46-9 for unambiguous identification.
- Commonly supplied in mg-scale quantities for analytical and research use.
- Typically provided at high purity suitable for research applications.
Medchemexpress LLC Trilaurin | 538-24-9 | 99.8% | 1 G
Trilaurin is an anticancer agent capable of inhibiting neoplasms initiated by dimethylbenzanthracene (DMBA) and promoted by croton oil. It functions as an endogenous metabolite.
- Inhibits neoplasm formation
- Functions as an endogenous metabolite
- Molecular weight: 639.00
- Chemical formula: C39H74O6
- Appears as a solid
- Color: White to off-white
- Purity: 99.78%
- Soluble in DMSO and DMF
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Sigma Aldrich Fine Chemicals Biosciences Glyceryl triacetate 99.0 G1L
Glyceryl TRIACETATE Glyceryl triacetate 99.0 G1L
Sigma Aldrich Fine Chemicals Biosciences Triacetin 99 fCC fG25KG
Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams nonalcoholic beverages and baked goods.
Medchemexpress LLC Tristearin | 555-43-1 | ≥98.0% | 500 MG
Tristearin (Glycerol tristearate) is a triglyceride derived from three units of stearic acid. It is commonly used as a solid-lipid nanoparticle (SLN) component for constructing drug delivery carriers, and has been shown to increase the cellular uptake rate of carried drugs, thereby enhancing drug efficacy.
- Triglyceride derived from stearic acid
- Used as a solid-lipid nanoparticle (SLN) component
- Increases cellular uptake rate of carried drugs
- Enhances drug efficacy
Medchemexpress LLC Triolein | 122-32-7 | 885.43 | 1 ML
Triolein is a symmetric triacylglycerol known for its ability to reduce the upregulation of MMP-1, an enzyme involved in various physiological and pathological processes. It also exhibits potent antioxidant and anti-inflammatory properties.
- Reduces upregulation of MMP-1 in dermal fibroblasts.
- Possesses strong antioxidant activities.
- Demonstrates strong anti-inflammatory activities.
- Decreases the upregulation of MMP-1 in dermal fibroblasts produced by reactive oxygen species.
- Can improve oxidative stress induced by oxidative low-density lipoprotein in endothelial cells.
Medchemexpress LLC Triolein | 122-32-7 | 885.43 | 50 MG
Triolein (Standard) is the analytical standard of Triolein, intended for research and analytical applications. It is a symmetric triacylglycerol that reduces the upregulation of MMP-1 and exhibits strong antioxidant and anti-inflammatory activities.
- Analytical standard for Triolein.
- Reduces upregulation of MMP-1.
- Possesses strong antioxidant activities.
- Possesses strong anti-inflammatory activities.
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
Electron Microscopy Sciences Triacetin Reagent 0.5 OZ
For your convenience Triacetin Reagent is avaialbe for use with the our Acetone Vaporizer Kit.
TARGETMOL CHEMICALS INC Trilinolein 500MG
Also available in 1 g, 1 mL, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Trilinolein (1,2,3-Trilinoleoylglycerol) is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. It is also an antioxidant. Purity 99.4%