Sphingolipids
Medchemexpress LLC C8 PEG750 ceramide | 212116-76-2 | 99.9% | 750.0 g/mol (average) | (C2H4O)nC31H57NO6 | 5 MG
C8 PEG750 ceramide is a PEGylated ceramide lipid used to form lipid bilayer carriers such as liposomes and lipid nanoparticles for selective delivery of diagnostic and therapeutic agents to acidic diseased cells. It is provided as a high-purity research reagent suitable for formulation development and analytical studies.
- High purity for reliable formulation and analysis.
- PEGylated ceramide structure for steric stabilization of lipid assemblies.
- Average molecular weight ~750 supports PEG shielding properties.
- Suitable for liposome and LNP formulation development.
- Available in small milligram pack sizes for research use.
TARGETMOL CHEMICALS INC C16 CERAMIDE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. C16 Ceramide (Palmitoyl Ceramide) is a natural small molecule activating p53 through the direct and selective binding. purity: 99%
Cayman Chemical C18 dIhydro CeramIde-d3d181mg
An internal standard for the quantification of C18 dihydro ceramide by GC- or LC-MS
Medchemexpress LLC C18:1-Ceramide | 5966-28-9 | 99.9% | C36H69NO3 | 50 MG
C18:1-Ceramide is a ceramide subspecies primarily used for research and analytical applications. It serves as an analytical standard and can be utilized in studies related to type 2 diabetes.
- Ceramide subspecies
- Intended for research and analytical applications
- Can be used in the study of type 2 diabetes
Medchemexpress LLC N-behenoyl-D-erythro-sphingosine | 27888-44-4 | C40H79NO3 | 5 MG
C22-Ceramide, also known as N-Behenoyl-D-erythro-sphingosine, is an endogenous bioactive sphingolipid. This compound has been observed to decrease the tendency of C16-ceramide to form channels in isolated rat liver mitochondria and in liposomes. Its primary application is for research purposes.
- Functions as an endogenous bioactive sphingolipid.
- Molecular weight: 622.06
- Formula: C40H79NO3
- CAS No.: 27888-44-4
- Appearance: Solid
- Color: White to off-white
- Purity: 99.89%
- Solubility: Ethanol: 5 mg/mL (8.04 mM) with ultrasonic and warming to 60°C.
- Solubility: DMF: 0.33 mg/mL (0.53 mM) with ultrasonic and warming to 60°C.
- Storage conditions (solid form): 4°C, protected from light.
- Storage conditions (in solvent): -80°C for 6 months, or -20°C for 1 month (protect from light).
Medchemexpress LLC 17:1 Lyso PC | 1246304-62-0 | C25H50NO7P | 50 MG
17:1 Lyso PC is a liposome designed to simulate biological phospholipid membranes. These liposomes, composed of concentric phospholipid bilayer membranes, can be utilized to create drug delivery systems for both anti-cancer and anti-infection applications. They are capable of trapping highly polar water-soluble payloads within their internal aqueous space, while lipophilic payloads can integrate into the lipid bilayer. This product is particularly effective for delivering antisense oligonucleotides, addressing issues such as inefficient cellular uptake and rapid loss within the body.
- Simulates biological phospholipid membranes
- Utilized for anti-cancer and anti-infection drug delivery systems
- Traps highly polar water-soluble payloads within internal aqueous space
- Integrates lipophilic payloads into the lipid bilayer
- Effective for delivering antisense oligonucleotides
Cayman Chemical C12 NBD Ceramide d18 1 12 0
C12 NBD ceramide (d18:1/12:0) is a long-chain fluorescent ceramide analog that can be used for the measurement of alkaline and neutral ceramidase activity.{14063} It is hydrolyzed efficiently by alkaline ceramidase from P. aeruginosa and by neutral ceramidase from mouse liver. In addition, alkaline and neutral ceramidases from a variety of mammalian cell lines also hydrolyze C12 NBD ceramide (d18:1/12:0). Acid ceramidase does not appear to utilize C12 NBD ceramide (d18:1/12:0) as a substrate. The possibility exists forC12 NBD ceramide (d18:1/12:0) to also be applied to the measurement of ceramide kinase and/or sphingomyelin synthase activity.
Apexbio Technology LLC Lyso-Tracker Green(Synonyms: LysoTracker Green DND-26, LysoTracker Green, LysoTracker Green lysosomal probe), 50ul.
Lyso-Tracker Green is a fluorescent small-molecule probe designed specifically for labeling lysosomes in living cells. As a weakly basic fluorophore, it accumulates selectively in acidic cellular compartments, primarily lysosomes, due to protonation under low pH conditions. Unlike conventional dyes such as acridine orange or neutral red, Lyso-Tracker Green exhibits superior organellar selectivity and requires only nanomolar concentrations to produce robust fluorescent labeling. It is widely utilized in biomedical research for imaging lysosomal localization and analyzing cellular physiology in live-cell assays, but is not compatible with fixed-cell staining protocols.
Medchemexpress LLC (E/Z)-N-Arachidoyl-D-sphingosine | 123482-93-9 | 99.9% | 594.01 | 1 MG
(E/Z)-C20 Ceramide ((E/Z)-N-Arachidoyl-D-sphingosine) is a mixture of (Z)-C20 Ceramide and (E)-C20 Ceramide. It is intended for research use only.
- Product is for research use only.
Medchemexpress LLC C20 Ceramide | 7344-02-7 | 99.1% | 594.01 | 1 MG
C20 Ceramide (N-Arachidoyl-D-sphingosine) is a natural 20:0 ceramide and an N-acylsphingosine where the ceramide N-acyl group is eicosanoyl. It acts as a key signal molecule mediating biological processes such as cell growth, differentiation, senescence, and apoptosis. This product is for research use only.
- Natural 20:0 ceramide and N-acylsphingosine
- Acts as a key signal molecule mediating biological processes
- Mediates cell growth, differentiation, senescence, and apoptosis
Medchemexpress LLC 24:0 Lyso PC-13C6 | 2483735-01-7 | 97.5% | 613.80 | 1 MG
24:0 Lyso PC-13C6 is the 13C labeled 24:0 Lyso PC. 24:0 Lyso PC is a lysophospholipid (LyP) that could be used for mRNA drug delivery. It can also be used as a tracer or as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC C16 PEG2000 Ceramide | 212116-78-4 | 99.4% | (C2H4O)nC39H73NO6 | 50 MG
C16 PEG2000 Ceramide is a polyethylene glycolylated ceramide that functions as a lipid carrier for delivery. It induces autophagy and is suitable for cancer research.
- Functions as a lipid carrier for delivery
- Induces autophagy
- Suitable for cancer research
- Exhibits cytotoxicity in N2a cells
- Promotes autophagy in N2a cells
- Increases LC3-II/LC3-I ratios in N2a cells
- Reduces WT-Tau and P301L-Tau proteins in N2a cells
Medchemexpress LLC C12-NBD Sphinganine | 474943-05-0 | 99.9% | C36H63N5O6 | 1 MG
C12-NBD Sphinganine is a fluorescent ceramidase substrate that can be used for the measurement of alkaline and neutral ceramidase activity from a variety of sources.
- Fluorescent ceramidase substrate
- Used for measuring alkaline and neutral ceramidase activity
- Molecular weight: 661.92
- Appearance: Solid
- Color: Light yellow to yellow
- Recommended storage at -20°C, sealed, away from moisture and light
- In solvent, stable for 6 months at -80°C or 1 month at -20°C