A pleuromutilin antibiotic active against various bacteria including MRSA (MIC50s 0.006-1 Ug/ml) active against fluoroquinolone- and macrolide-resistant strains of N. gonorrhoeae (MIC90s 1 mg/L for all) reduces the number of CFUs in a mouse model of S. pneumoniae thigh infection from 10-40 mg/kg reduces LPS-induced production of TNF-a IL-6 IL-1B and GM-CSF BALF neutrophil infiltration and lung MMP-9 levels in a mouse model of LPS-induced neutrophilia
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Sphingomyelinase (SMase) or sphingomyelin phosphodiesterase catalyzes the hydrolytic cleavage of sphingolipid to phosphocholine and ceramide a second messenger involved in multiple cellular responses including the cellular response to stress. There are at least 5 types of SMases identified which are classified according to their cation dependence cellular location and pH optima for activity and include the acidic and neutral sphingomyelinase. Neutral SMases along with the acidic SMases are thought to be major contributors to the production of ceramide in response to cellular stress.
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Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. C14 Ceramide is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's research. Purity 99.63%
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase. Purity: ≥98% (TLC). Solubility: Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C). Long Term Storage: -20°C.
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A peptide analog of oxytocin that antagonizes the human oxytocin receptor (Ki 81 nM) has tocolytic actions in the acute phase of imminent preterm birth
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ABadrenergic receptor antagonist that acts as a vasodilator and increases ocular circulation formulations containing levobunolol are used to manage glaucoma
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A pleuromutilin antibiotic active against various bacteria including MRSA (MIC50s 0.006-1 Ug/ml) active against fluoroquinolone- and macrolide-resistant strains of N. gonorrhoeae (MIC90s 1 mg/L for all) reduces the number of CFUs in a mouse model of S. pneumoniae thigh infection from 10-40 mg/kg reduces LPS-induced production of TNF-a IL-6 IL-1B and GM-CSF BALF neutrophil infiltration and lung MMP-9 levels in a mouse model of LPS-induced neutrophilia
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More