Steroids and derivatives
Apexbio Technology LLC Deoxycorticosterone acetate 56-47-3 50mg
Deoxycorticosterone acetate (56-47-3) is a small-molecule agonist targeting mineralocorticoid receptors (MR) It is designed to activate MR thereby regulating renal sodium reabsorption and potassium excretion Deoxycorticosterone acetate exerts its biological activity primarily through interaction with cytoplasmic mineralocorticoid receptors leading to nuclear translocation and modulation of electrolyte balance Typical IC50 values associated with its mineralocorticoid receptor binding affinity have been reported in the nanomolar range Based on these pharmacological properties Deoxycorticosterone acetate holds research potential in studies of electrolyte balance adrenal insufficiency modeling and the pathophysiology of hypertension as well as models investigating mineralocorticoid receptor-dependent signaling and renal or cardiovascular physiology
Apexbio Technology LLC Medroxyprogesterone 520-85-4 50mg
Medroxyprogesterone (CAS 520-85-4) is a small-molecule agonist targeting the progesterone receptor It is designed to activate progesterone receptor-mediated intracellular signaling pathways thereby regulating cellular proliferation Medroxyprogesterone exerts its biological activity primarily through agonism of the progesterone receptor modulating pathways such as PI3K/Akt signaling In preclinical mouse models medroxyprogesterone demonstrates inhibitory activity on atherosclerotic lesion formation Based on these pharmacological properties medroxyprogesterone holds research potential in the study of progesterone receptor-mediated biological processes cellular proliferation and vascular pathology
Medchemexpress LLC 1-Methylinosine-d3 | 2140-73-0 | 99.0% | 285.27 | 1 MG
1-Methylinosine-d3 is a deuterium-labeled version of 1-Methylinosine. 1-Methylinosine is a modified nucleotide found at position 37 in the tRNA 3' to the anticodon of eukaryotic tRNA. This product is for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuterium substitution can affect pharmacokinetic and metabolic profiles.
Medchemexpress LLC 1α,25-dihydroxy-3-epi-vitamin D3 | 61476-45-7 | MFCD28963706 | 98.5% | 416.64 g·mol⁻1 | C27H44O3 | 5 MG
1S-Calcitriol is a stereoisomer of calcitriol (1α,25-dihydroxyvitamin D3) that functions as a potent vitamin D receptor (VDR) agonist. It is provided as a high-purity solid research reagent for use in cellular, biochemical, and pharmacological studies of VDR signaling, calcium homeostasis, and related physiological processes.
- Potent vitamin D receptor agonist.
- Useful for studying keratinocyte proliferation and differentiation.
- Supports investigation of parathyroid hormone regulation and calcium signaling.
- Provided as a high-purity solid for analytical and biological assays.
- Chemical formula C27H44O3; molecular weight 416.64 g·mol⁻1.
Medchemexpress LLC Elexacaftor-d3 (VX-445-d3) | 2216712-66-0 | 98.3% | 600.67 | 1 MG
Elexacaftor-d3 (VX-445-d3) is a deuterium labeled compound, serving as a tracer and internal standard for quantitative analysis methods such as NMR, GC-MS, or LC-MS. Deuteration may influence the pharmacokinetic and metabolic profiles of drugs. Its unlabeled counterpart, Elexacaftor (VX-445), acts as a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, aiming to restore Phe508del CFTR protein function and treat cystic fibrosis.
- Deuterium labeled compound
- Used as a tracer
- Used as an internal standard for quantitative analysis
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Has potential to treat cystic fibrosis
- Improves Phe508del CFTR protein processing, trafficking, and chloride transport
Cayman Chemical ArachIdIc AcId-d3 10mg
An internal standard for the quantification of arachidic acid by GC- or LC-MS
BIOHIPPO AAV-D2-BFP-WPRE-hGH-pA
Recombinant adeno associated virus expressing BFP under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Cambridge Isotope Laboratories Melatonin (acetyl-D3 98%) CP 95% 10 mg
Melatonin (acetyl-D3 98%) CP 95% 10 mg
BIOHIPPO AAV-D2-hChR2(E123T/T159C)-mCherry-WPRE-hGH-polyA
Recombinant adeno associated virus expressing hChR2(E123T/T159C) fused to mCherry under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
BIOHIPPO AAV-D2-GCaMP6m-WPRE-hGH--polyA
Recombinant adeno associated virus expressing GCaMP6m under the D2 promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Medchemexpress LLC Sulfadoxine-d3 | 1262770-70-6 | 98.0% | 5 MG
Sulfadoxine-d3 is a deuterium labeled Sulfadoxine, a sulfonamide used for multidrug-resistant *Plasmodium falciparum* and *P. vivax* inhibition, typically with Pyrimethamine. It does not affect HIV replication or MT-2 cell cycle progression, and also suppresses respiratory and urinary tract infections.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Used for multidrug-resistant *Plasmodium falciparum* and *P. vivax* inhibition
- Exhibits suppression on respiratory and urinary tract infections
- Has no impact on HIV replication or MT-2 cell cycle progression
Cayman Chemical 4-hydroxy Nonal-d3 100ug
An internal standard for the quantification of 4-HNE by GC- or LC-MS
Medchemexpress LLC Trans-doxercalciferol | 74007-20-8 | MFCD01076571 | 98.2% | 412.65 | C28H44O2 | 10 MG
trans-Doxercalciferol is an isomer of doxercalciferol (a vitamin D2 analog) that activates the vitamin D receptor (VDR). Supplied as a research-grade powder for in vitro and analytical use, it has a molecular weight of 412.65 g/mol and a reported purity of 98.2%.
- Is an isomer of doxercalciferol and a vitamin D2 analog.
- Activates the vitamin D receptor (VDR) and is used in vitamin D signaling research.
- High reported purity (98.2%).
- Available in multiple pack sizes, including 10 mg.
- Powder storage: -20°C for long-term, 4°C for short-term stability.
TARGETMOL CHEMICALS INC 5-6-TRANS-VITAMIN D3 5MG
Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. 56-trans-Vitamin D3（56-trans-Cholecalciferol） is an isoform of Vitamin D3 which is converted from Vitamin D3 on the skin surface after light exposure. purity: 97%
Medchemexpress LLC Thymidine-α,α,α-d3 | 74848-84-3 | 245.25 | 1 MG
Thymidine-d3 is deuterium labeled Thymidine, a specific precursor of deoxyribonucleic acid used as a cell synchronizing agent. It functions as a DNA synthesis inhibitor, capable of arresting cells at the G1/S boundary before DNA replication. Deuterium substitution has the potential to affect pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.