Purine nucleotides
Apexbio Technology LLC 8-AZIDO-ATP 10UL 100 MM
8-Azido-ATP is a ribonucleoside triphosphate analog with an azido group substitution at the adenine C-8 position It acts primarily as an ATP mimic interacting with poly(A) polymerase (PAP) specifically illustrated using yeast poly(A) polymerase (yPAP) Incorporation of 8-azido-ATP into growing polyadenylation chains results in premature termination and moderately shorter poly(A) tails relative to natural ATP substrates Due to its chain-terminating capacity and altered substrate specificity 8-azido-ATP is applied in biochemical studies examining enzyme fidelity nucleotide selection mechanisms and RNA polymerase activity
Apexbio Technology LLC 2-O-METHYL-ATP 50UL 100 MM
2 -O-Methyl-ATP is a chemically modified derivative of ATP in which the hydroxyl group at the ribose 2 position is replaced with a methyl group This ribose modification confers resistance to nuclease-mediated degradation thereby increasing its biological stability The modified nucleotide is commonly employed in biomedical research to investigate RNA structure-function relationships and RNA modification pathways and to study interactions influencing RNA polymerase specificity and catalytic activity Additionally 2 -O-Methyl-ATP serves as a tool in probe design for RNA interference experiments and aids in elucidating intracellular metabolic pathways involving nucleotide analogs
Apexbio Technology LLC 2-AMINO-ATP 10UL 100 MM
2-Amino-ATP is a modified nucleotide structurally related to ATP (adenosine triphosphate) featuring an amino substitution at the adenine ring s 2-position It acts as an ATP analog capable of competitively binding at the active sites of ATP-dependent enzymes potentially modulating their enzymatic activity and influencing downstream signaling pathways In research settings 2-Amino-ATP serves as a molecular tool to examine substrate specificity mechanistic aspects of ATP-binding enzymes (e g kinases and ATPases) and nucleotide-dependent receptor interactions facilitating studies of nucleotide signaling and cellular metabolism
Apexbio Technology LLC 7-DEAZA-ATP 100UL 100 MM
7-Deaza-ATP is a chemically modified ATP analog wherein the nitrogen atom at position 7 of the adenine ring is replaced by a carbon atom This structural alteration modulates its interactions with enzymes and nucleic acid-binding proteins As a nucleotide analog 7-Deaza-ATP can be incorporated into DNA and RNA strands thereby influencing polymerase enzyme activity and subsequently affecting nucleotide synthesis replication and repair processes Due to these properties this molecule is applied in investigating nucleotide-protein binding specificity and the catalytic mechanisms of enzymes facilitating research towards nucleotide-targeted therapeutic strategies
Apexbio Technology LLC Chloroquine diphosphate 50-63-5 10mM (in 1mL H2O)
Chloroquine diphosphate is an antimalarial agent and inhibitor of TLR7 and TLR9 commonly used in biomedical research to modulate autophagic processes On the cellular level chloroquine diphosphate promotes autophagy through cell cycle arrest at the G1 phase involving increased expression of p27 and p53 and decreased levels of CDK2 and cyclin D1 Additionally chloroquine diphosphate enhances sensitivity of cancer cells toward chemotherapy and radiotherapy treatments by elevating autophagy and apoptotic responses In vitro studies demonstrated dose-dependent activity with reported IC50 values typically ranging from approximately 15 to 40 M depending on cell types This compound is widely utilized as an autophagy modulator and therapeutic adjuvant in tumor cell models
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5-triphosphate disodium salt hydrate BioXtra, 99 (HPLC), from microbial, 34369-07-8, MFCD00150755
Adenosine 5-triphosphate disodium salt hydrate BioXtra, 99 (HPLC), from microbial
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5-triphosphate disodium salt hydrate BioXtra, 99 (HPLC), from microbial, 34369-07-8, MFCD00150755
Adenosine 5-triphosphate disodium salt hydrate BioXtra, 99 (HPLC), from microbial
![Research Products International Corp ATP [Adenosine-5'-triphosphate, disodium salt trihydrate], 1 Gram](https://assets.fishersci.com/TFS-Assets/CCG/product-images/VN00006095-A30030-1.0.JPG-250.jpg)
Research Products International Corp ATP [Adenosine-5'-triphosphate, disodium salt trihydrate], 1 Gram
An essential nucleotide triphosphate with a variety of roles in energy metabolism, signal transduction and nucleic acid metabolism.
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | 34369-07-8 | MFCD00150755 | 500G
Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | Purity: >=97% (HPLC) | 34369-07-8 | MFCD00150755 | 500G
Sigma Aldrich Fine Chemicals Biosciences Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | 34369-07-8 | MFCD00150755 | 10G
Adenosine 5'-triphosphate disodium salt hydrate Grade II, >=97% (HPLC), crystalline, from microbial | Purity: >=97% (HPLC) | 34369-07-8 | MFCD00150755 | 10G
Sigma Aldrich Fine Chemicals Biosciences Hexanoyl coenzyme A trilithium salt hydrate >=85% | 103476-19-3 (anhydrous) | 5MG
Hexanoyl coenzyme A trilithium salt hydrate >=85% | Purity: >=85% | 103476-19-3 (anhydrous) | 5MG