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Two-carbon nitrogen ring bases (adenine and guanine) covalently linked to a sugar (ribose or deoxyribose) and one to three phosphate groups; can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
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Guanosine 5'-triphosphate-5'-adenosine (GpppA) triammonium is a 5' cap analog that can be used for RNA synthesis in vitro. It is also described as a fluorescent substrate analog.
Fluorescent substrate analog.
Can be used for RNA synthesis in vitro.
Acts as an artificial substrate when labeled with pyrene at the 3′-O position of adenosine.
Fluorescently labeled GpppA triammonium and GpppG analogs are potential substrates that balance structural complexity and enzymatic requirements.
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BRM/BRG1 ATP Inhibitor-2 is a BRG1/BRM ATPase inhibitor for the research of BAF-related disorders. This product is intended for research use only and not for sale to patients.
BRG1/BRM ATPase inhibitor
Used for research of BAF-related disorders
Targets epigenetic reader domain
Involved in epigenetics pathway
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Adenosine receptor antagonist 2 is an orally active A2a/A2b adenosine receptor antagonist with IC50s of 1 nM and 3 nM, respectively. It has anti-tumor activity.
Orally active A2a/A2b adenosine receptor antagonist
IC50s of 1 nM (A2a) and 3 nM (A2b)
Anti-tumor activity
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GTP-Binding Protein Fragment G alpha is a peptide fragment derived from the amino-terminal region of the alpha subunit of GTP-binding proteins It is designed to aid in elucidating the mechanisms of membrane association and -subunit interactions in cell signaling pathways GTP-Binding Protein Fragment G alpha exerts its biological activity by retaining membrane-binding properties independent of the nucleotide-binding state anchoring the protein to the cytoplasmic membrane surface This peptide fragment serves as an experimental tool to study membrane-association mechanisms and signal transduction pathways in biochemical and biomedical research Based on these properties GTP-Binding Protein Fragment G alpha holds research potential in investigating the molecular basis of G protein-mediated signal transduction and protein-membrane interactions
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NHC-triphosphate tetraammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) in its triphosphate form. It acts as a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA.
May directly target the viral polymerase and act as a nonobligate chain terminator
Plays a significant role in inhibiting early negative-strand RNA synthesis
Interferes with correct replicase complex formation through chain termination or mutagenesis
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Kinetin triphosphate tetrasodium is an ATP analogue provided as the tetrasodium salt for biochemical research. It modulates kinase activity and has documented use in studies such as Parkinson's disease research. Supplied as a small, concentrated vial suitable for in vitro kinase assays and mechanistic studies.
High purity (99.92%).
Supplied as the tetrasodium salt, water-soluble for aqueous assays.
Provided in small vial sizes (5 mg; 100 mM when dissolved as indicated by supplier).
Suitable for kinase activity assays and mechanistic studies.
Datasheet, certificate of analysis, and safety data sheet available for quality and safety information.
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7-Deaza-ATP is a chemically modified ATP analog wherein the nitrogen atom at position 7 of the adenine ring is replaced by a carbon atom This structural alteration modulates its interactions with enzymes and nucleic acid-binding proteins As a nucleotide analog 7-Deaza-ATP can be incorporated into DNA and RNA strands thereby influencing polymerase enzyme activity and subsequently affecting nucleotide synthesis replication and repair processes Due to these properties this molecule is applied in investigating nucleotide-protein binding specificity and the catalytic mechanisms of enzymes facilitating research towards nucleotide-targeted therapeutic strategies
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