Drug Standards
Medchemexpress LLC Pantoprazole (sodium) | 138786-67-1 | 99.8% | 405.35 | 1 ML
Pantoprazole sodium (BY1023 sodium) is an orally active and potent proton pump inhibitor (PPI). This substituted benzimidazole acts as a strong H+/K+-ATPase inhibitor with an IC50 of 6.8 μM. It enhances pH stability and exhibits anti-secretory and anti-ulcer properties. When combined with Doxorubicin, Pantoprazole sodium significantly increased tumor growth delay.
- Potent H+/K+-ATPase inhibitor
- Improved pH stability
- Anti-secretory activity
- Anti-ulcer activity
- Potential in cancer therapy
- Blocks exosome release
- Impairs tumor cell acidification
Medchemexpress LLC Levoketoconazole | 142128-57-2 | 99.4% | C26H28Cl2N4O4 | 100 MG
Levoketoconazole is the 2S,4R enantiomer derived from racemic Ketoconazole. It is a potent and orally active cortisol synthesis inhibitor. It inhibits key steps in cortisol and testosterone synthesis by inhibiting CYP11B1, CYP11A1, and CYP17A1. It can be used for research on endogenous Cushing's syndrome.
- Potent and orally active cortisol synthesis inhibitor
- Inhibits key enzymes: targets CYP11B1, CYP11A1, and CYP17A1
- Useful for research on endogenous Cushing's syndrome
- High purity: 99.39% pure
- Enantiomer specific: 2S,4R enantiomer of Ketoconazole
Medchemexpress LLC Cytidine, 2'-deoxy-2',2'-difluoro-, hydrochloride | 122111-03-9 | 99.9% | C9H12ClF2N3O4 | 1 ML
Gemcitabine hydrochloride is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. It inhibits DNA synthesis and repair, leading to autophagy and apoptosis.
- Targets DNA/RNA synthesis
- Functions as a nucleoside antimetabolite/analog
- Induces autophagy and apoptosis
- Used in cancer research
Medchemexpress LLC Ketoconazole-d4 | 1398065-75-2 | 99.63% | C26H24D4Cl2N4O4 | 1 MG
Ketoconazole-d4 is a deuterium labeled form of Ketoconazole, which is an imidazole anti-fungal agent and a CYP3A4 and CYP24A1 inhibitor. Stable heavy isotopes, such as deuterium, are incorporated into drug molecules primarily as tracers for quantitation during the drug development process. Deuteration has garnered attention due to its potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuterium labeled compound
- Inhibits CYP3A4 and CYP24A1
- Acts as an anti-fungal agent
- Suitable for research use only
Medchemexpress LLC Acarbose | 56180-94-0 | 99.97% | C25H43NO18 | 10 MM/1 ML
Acarbose is an orally active alpha-glucosidase inhibitor and an antihyperglycemic agent. It works by slowing the digestion and absorption of complex carbohydrates, thereby leading to a more gradual rise in blood glucose levels after meals. Primarily used in the management of type 2 diabetes mellitus, it can potentiate the hypoglycemic effects of sulfonylureas or insulin.
- Antihyperglycemic agent
- Orally active alpha-glucosidase inhibitor (IC50=11 nM)
- Potentiates hypoglycemic effects of sulfonylureas or insulin
- Slows digestion and absorption of carbohydrates
- Used for management of type 2 diabetes mellitus
- Available as a solid, white to light yellow powder
- Soluble in water
Medchemexpress LLC Donepezil-d5 hydrochloride | 1883548-90-0 | C24H25D5ClNO3 | 1 MG
Donepezil-d5 (hydrochloride) is a deuterium labeled version of Donepezil (Hydrochloride), which is a reversible and selective AChE inhibitor with an IC50 of 6.7 nM. It demonstrates high selectivity for AChE over BuChE and has shown neuroprotective effects against Aβ42 neurotoxicity. This product is for research use only and has not been fully validated for medical applications.
- Stable heavy isotopes used as tracers for quantitation
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- For research use only
Medchemexpress LLC Granisetron Hydrochloride | 107007-99-8 | 99.9% | C18H25ClN4O | 100 MG
Granisetron Hydrochloride is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. This product is for research use only.
- Serotonin 5-HT3 receptor antagonist
- Used as an antiemetic for chemotherapy-induced nausea and vomiting
- White to off-white solid appearance
- Purity of 99.9%
- Molecular weight of 348.87
- CAS number 107007-99-8
Medchemexpress LLC Benazepril | 86541-75-5 | 99.85% | C24H28N2O5 | 1 ML
Benazepril is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces angiotensin-II production. It inhibits oxidative stress and apoptosis via the PI3K/Akt signaling pathway. This compound improves diabetic nephropathy, decreases proteinuria, and is used in the study of hypertension, heart failure, and diabetic nephropathy.
- Orally active ACE inhibitor
- Reduces angiotensin-II production
- Inhibits oxidative stress and apoptosis via PI3K/Akt signaling pathway
- Improves diabetic nephropathy
- Decreases proteinuria
- Used in the study of hypertension, heart failure, and diabetic nephropathy
- Alleviates oxidative stress and inhibits cell apoptosis in H9c2 cells (in vitro)
- Decreases proteinuria, urea, creatinine, triglycerides, and total cholesterol in diabetic nephropathy rat models (in vivo)
Medchemexpress LLC Ketoconazole (Standard) | 65277-42-1 | C26H28Cl2N4O4 | 5 G
Ketoconazole is an imidazole anti-fungal agent, functioning as a CYP3A4 and CYP24A1 inhibitor. It has been studied for its role in inhibiting cytochrome P450 and its antischistosomal potential against Schistosoma mansoni infection.
- Functions as an imidazole anti-fungal agent
- Inhibits CYP3A4 and CYP24A1
- Inhibits cytochrome P450
- Demonstrates antischistosomal potential
- Enhances antiproliferative effects
- Increases systemic calcitriol exposure
- Promotes activation of the caspase-independent apoptosis pathway
- Potent exosome biogenesis and/or secretion inhibitor
Medchemexpress LLC Benazepril hydrochloride | 86541-74-4 | 99.96% | C24H29ClN2O5 | 5 G
Benazepril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor that reduces angiotensin-II production. It inhibits oxidative stress and apoptosis via the PI3K/Akt signaling pathway. Additionally, Benazepril hydrochloride improves diabetic nephropathy and decreases proteinuria, making it suitable for studies of hypertension, heart failure, and diabetic nephropathy.
- Orally active ACE inhibitor
- Reduces angiotensin-II production
- Inhibits oxidative stress and cell apoptosis
- Improves diabetic nephropathy and decreases proteinuria
- Used in studies of hypertension, heart failure, and diabetic nephropathy
Medchemexpress LLC Tofacitinib Impurity T | 1675248-19-7 | 99.8% | C16H22N6O2 | 5 MG
Tofacitinib Impurity T is a drug intermediate used for the synthesis of various active compounds. It is intended for research use only.
- Drug intermediate for synthesis
- For research use only
- Molecular Weight: 330.39
- Appearance: Solid
- Shipping: Room temperature (continental US)
- Storage: -20°C for 3 years (powder), -80°C for 6 months (in solvent)
Medchemexpress LLC Voriconazole (Standard) | 137234-62-9 | 99.90% | C16H14F3N5O | 5 MG
Voriconazole (Standard) is the analytical standard of Voriconazole, intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Its antifungal activity is exerted through the inhibition of 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes.
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard for research and analytical applications.
- Inhibits fungal ergosterol biosynthesis.
- Exerts antifungal activity by inhibiting 14-α-lanosterol demethylation.
Medchemexpress LLC Enzalutamide | 915087-33-1 | MFCD14155804 | 99.97% | C21H16F4N4O2S | 1 ML
Enzalutamide, also known as MDV3100, is a potent androgen receptor (AR) antagonist that exhibits an IC50 of 36 nM in LNCaP prostate cells. It also functions as an autophagy activator. This product is for research use only.
- Functions as an androgen receptor antagonist
- Potent activity with IC50 of 36 nM in LNCaP prostate cells
- Acts as an autophagy activator
- Suitable for research applications
Medchemexpress LLC Voriconazole | 137234-62-9 | 99.5% | C16H14F3N5O | 5 MG
Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent. It inhibits fungal ergosterol biosynthesis by inhibiting 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes. It is also capable of penetrating the blood-brain barrier (BBB).
- Inhibits fungal ergosterol biosynthesis.
- Inhibits 14-α-lanosterol demethylation.
- Penetrates the blood-brain barrier.
- Active against *S. apiospermum* (MIC 0.5 μg/mL) and *C. neoformans* (MIC 0.125-0.25 μg/mL).
- Disrupts fungal cell membranes and halts growth.
Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | C30H41N7O8S2 | 100 MG
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor, effective against EGFRL858R and EGFRL858R/T790M with IC50s of 12 and 1 nM respectively. It demonstrates similar potency to early generation tyrosine kinase inhibitors (TKIs) in inhibiting EGFR phosphorylation in EGFR cells and potently inhibits phosphorylation in T790M mutant cell lines. This compound offers improved rat PK, reduced hERG affinity, and enhanced IGF1R margins. Its profile provides broader chemical diversity, showing comparable efficacy at low doses.
- Irreversible and mutant selective EGFR inhibitor
- Potently inhibits EGFR phosphorylation in T790M mutant cell lines
- Improved rat PK and reduced hERG affinity
- Broader chemical and profile diversity
- Comparable efficacy at low doses