Drug Standards
Medchemexpress LLC Spironolactone (Standard) | 52-01-7 | 98.6% | 100 MG
Spironolactone (Standard) serves as the analytical standard for Spironolactone. It is designed for research and analytical applications. Spironolactone (SC9420) is an orally active antagonist of the aldosterone mineralocorticoid receptor, with an IC50 of 24 nM. It also acts as a potent antagonist of the androgen receptor, exhibiting an IC50 of 77 nM. Furthermore, Spironolactone has been shown to promote autophagy in podocytes.
- Intended for research and analytical applications
- Analytical standard for Spironolactone
- Orally active aldosterone mineralocorticoid receptor antagonist (IC50 of 24 nM)
- Potent antagonist of androgen receptor (IC50 of 77 nM)
- Promotes autophagy in podocytes
- Used in qualitative, quantitative, and methodological research experiments
- Suitable for HPLC, GC, and MS applications
Medchemexpress LLC Amoxicillin (sodium) | 34642-77-8 | 98.0% | 5 G
Amoxicillin (sodium) is an antibiotic with good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby inhibiting cell growth. This product is intended for research use only.
- Inhibits biosynthesis of polypeptides in the cell wall
- Decreases living cells and increases cell wall rupture in L. acidophilus (in vitro)
- Inhibits bacterial numbers in mice (in vivo)
- Improves activity against Chlamydia trachomatis infection (in vivo)
- Supporting documentation available, including data sheets, COA, and SDS
Medchemexpress LLC Ciclopirox (olamine) | 41621-49-2 | 99.8% | 50 MG
Ciclopirox olamine is a synthetic, orally active antifungal agent for superficial mycoses research. It exhibits a broad spectrum of activity against dermatophytes, yeasts, molds, and various Gram-positive and Gram-negative pathogenic species. This compound also demonstrates anticancer and anti-inflammatory effects.
- Inhibits dermatophytes, yeasts, and molds
- Active against Gram-positive and Gram-negative species
- Shows anticancer activity in various cell lines and xenograft models
- Exhibits anti-inflammatory effects
- Inhibits HUVEC proliferation and angiogenesis
- Induces cell aerobic glycolysis and impairs mitochondrial functions
Medchemexpress LLC (R)-Ketorolac | 66635-93-6 | 99.7% | 10 MM 1 ML
(R)-Ketorolac is an orally active inhibitor of Cdc42 and Rac1. It inhibits GTPase and modifies ovarian cancer cell behaviors crucial for invasion and metastasis. This compound also ameliorates cancer-associated cachexia.
- Inhibits Cdc42 and Rac1
- Inhibits GTPase activity
- Modifies ovarian cancer cell behaviors for invasion and metastasis
- Ameliorates cancer-associated cachexia
- Decreases filopodia number and length
- Reduces cell adherence to fibronectin and collagen
- Prolongs survival in C26 tumour-bearing mice
- Alleviates C26-induced weight loss
- Prevents C26-induced T-lymphopenia
Medchemexpress LLC Betahistine-d3 dihydrochloride | 244094-72-2 | 99.0% | 5 MG
Betahistine-d3 dihydrochloride is a deuterium-labeled form of Betahistine dihydrochloride, an orally active histamine H1 receptor agonist and H3 receptor antagonist used in the study of rheumatoid arthritis (RA). Stable heavy isotopes, like deuterium in this molecule, are incorporated into drug molecules primarily as tracers for quantitation during the drug development process, and deuteration can impact the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Norfloxacin | 70458-96-7 | 99.8% | 250 MG
Norfloxacin (Standard) is the analytical standard of Norfloxacin. This product is intended for research and analytical applications. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, functioning by inhibiting DNA gyrase. It is commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS.
- Analytical standard
- Broad-spectrum antibiotic
- Active against Gram-positive and Gram-negative bacteria
- Inhibits DNA gyrase
- Suitable for research and analytical applications
- Used in HPLC, GC, and MS research experiments
Medchemexpress LLC Tebipenem pivoxil | 161715-24-8 | 99.7% | 100 MG
Tebipenem pivoxil (L084) is an orally active antibiotic that targets a broad spectrum of pathogenic bacteria. It functions by binding to penicillin-binding protein (PBP), which inhibits bacterial cell wall synthesis. This mechanism makes it a promising agent for treating various infections.
- Orally active antibiotic
- Effective against a variety of pathogenic bacteria
- Binds to penicillin-binding protein (PBP)
- Inhibits bacterial cell wall synthesis
- Demonstrates excellent antibacterial activity with MIC50s below 64 μg/mL against tested Gram-positive and Gram-negative bacteria in vitro
- In vivo studies show significant protection for sepsis mice challenged with various pathogenic bacteria
Medchemexpress LLC Betahistine dihydrochloride | 5579-84-0 | 99.8% | 25 G
Betahistine dihydrochloride is an orally active histamine H1 receptor agonist and a H3 receptor antagonist. It is used for the study of rheumatoid arthritis (RA).
- Orally active histamine H1 receptor agonist and H3 receptor antagonist
- Used for the study of rheumatoid arthritis
- Regulates cAMP formation in CHO cells
- Ameliorates collagen-induced arthritis in mouse models
- Has potential applications in various clinical conditions
Medchemexpress LLC Felodipine | 72509-76-3 | 99.83% | 50 MG
Felodipine is a dihydropyridine, a potent and vasoselective calcium channel antagonist. It effectively lowers blood pressure by targeting vascular smooth muscle, particularly in resistance vessels. This anti-hypertensive agent also possesses the ability to induce autophagy and can penetrate the blood-brain barrier.
- Potent vasoselective calcium channel antagonist
- Lowers blood pressure by acting on vascular smooth muscle
- Induces autophagy
- Able to cross the blood-brain barrier
Medchemexpress LLC Larotrectinib sulfate | 1223405-08-0 | 99.0% | 10 MG
Larotrectinib sulfate is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
- ATP-competitive oral inhibitor
- Selective inhibitor of TRK family receptors
- Low nanomolar inhibitory concentrations against TRKA, B, and C isoforms
Medchemexpress LLC Fostamatinib | 901119-35-5 | 99.7% | 200 MG
Fostamatinib (R788) is an oral proagent of the active compound R406. R406 is a competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. It also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Oral proagent of the active compound R406
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn
- Inhibits Lck
Medchemexpress LLC Fostamatinib disodium hexahydrate | 914295-16-2 | 99.5% | 50 MG
Fostamatinib disodium hexahydrate is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor, also inhibiting Lyn and Lck. This product is for research use only.
- Oral proagent of R406
- Orally available
- Competitive Syk/FLT3 inhibitor
- Inhibits Lyn and Lck
- For research use only
Medchemexpress LLC Fostamatinib (disodium hexahydrate) | 914295-16-2 | 99.5% | 100 MG
Fostamatinib (disodium hexahydrate) is a chemical compound commonly used as a laboratory chemical and for the manufacture of substances. It appears as a white to gray solid with a high purity of 99.5%. It is recommended for sealed storage away from moisture at 4°C, or at -80°C for 6 months (-20°C for 1 month) when in solvent.
- Used in laboratory research
- Suitable for substance manufacturing
- High purity (99.5%)
- Recommended sealed storage at 4°C, away from moisture
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
- Shipping at room temperature if less than 2 weeks
- White to gray solid appearance
Medchemexpress LLC Fostamatinib Disodium | 1025687-58-4 | 98.3% | 200 MG
Fostamatinib Disodium is an oral prodrug of the active compound R406. It acts as an orally available and competitive Syk/FLT3 inhibitor, also demonstrating inhibitory activity against Lyn and Lck. This compound is intended for research purposes only.
- Oral prodrug of R406
- Orally available
- Competitive Syk/FLT3 inhibitor (Ki of 30 nM, IC50 of 41 nM)
- Inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)
- Intended for research use only
Medchemexpress LLC Fostamatinib (R788) | 901119-35-5 | 99.7% | 100 MG
Fostamatinib (R788) is an oral proagent of the active compound R406. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM).
- Inhibits Syk and FLT3, as well as Lyn and Lck.
- Highly bioavailable and rapidly absorbed, converting completely to R406 in plasma.
- Intended for research purposes only; not for sale to patients.