Acetylides
Medchemexpress LLC Propargyl-PEG6-NH2 | 1198080-04-4 | 99.7% | 250 MG
Propargyl-PEG6-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group for CuAAc reactions
- Exploits the intracellular ubiquitin-proteasome system to degrade target proteins
Medchemexpress LLC Tert-butyl 3,6,9,12-tetraoxapentadec-14-ynoate | 888010-02-4 | MFCD28122944 | >95.0% | C15H26O6 | 10MG
Propargyl-PEG3-OCH2-Boc is a Boc-protected PEG3 linker with a terminal propargyl (alkyne) group, designed for use as a building block in click chemistry and linker synthesis. It enables selective conjugation and orthogonal deprotection steps in multi-step synthetic workflows.
- Provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition.
- Boc protecting group enables orthogonal deprotection in multi-step syntheses.
- PEG3 spacer imparts hydrophilicity and flexible linker length.
- Supplied in small pack sizes suitable for medicinal chemistry applications.
- Characterized by defined molecular weight and formula for reproducible reactions.
Medchemexpress LLC Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate) | 1119249-30-7 | 98.2% | 250 MG
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker used in the synthesis of Thalidomide-O-PEG2-propargyl. It functions as a click chemistry reagent, incorporating an Alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker, one for an E3 ubiquitin ligase and the other for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can be used to synthesize Thalidomide-O-PEG2-propargyl
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins