Acetylides
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 5 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 5 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 30 mL HDPE
- Pack Size: 5 g
- Net Weight: 5 g
- Gross Weight: 16.5 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 1 G
Propargyl-PEG7-NHS ester is an alkyne-functional PEG7 N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation. It couples to primary amines via NHS chemistry and provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, making it suitable for ADC, PROTAC, and general labeling applications.
- Alkyne-functional terminal enables click chemistry.
- NHS ester reacts with primary amines for covalent coupling.
- PEG7 spacer increases solubility and provides flexibility.
- Molecular weight about 489.51 g/mol and formula C22H35NO11.
- Typical applications include ADC linkers, PROTAC synthesis, and peptide or protein labeling.
eMolecules 3-Bromo-2-ethynylpyridine | 96439-99-5 | MFCD18256373 | 1g
Ambeed | 3-Bromo-2-ethynylpyridine | 1g | 600847246 | A758874 | | 96439-99-5 | MFCD18256373 | 182.020 | C7H4BrN
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eMolecules 3-Fluoro-4-(trifluoromethoxy)phenol | 177596-38-2 | MFCD06660342 | 1g
Apollo Scientific | 3-Fluoro-4-(trifluoromethoxy)phenol | 1g | 562451566 | PC10448 | | 177596-38-2 | MFCD06660342 | 196.101 | C7H4F4O2
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Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 100 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This mechanism exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) | 2112732-01-9 | 519.58 | 25 MG
N-(Propargyl-PEG4-carbonyl)-N-bis(PEG1-methyl ester) is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs and acts as a click chemistry reagent. This linker contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that possess azide groups.
- PEG-based PROTAC linker
- Utilized in the synthesis of PROTACs
- Acts as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC 4,7,10,13,16,19,22-heptaoxapentacos-24-ynoic acid | 2093154-00-6 | MFCD30536167 | 98.0% | 392.44 g·mol-1 | C18H32O9 | 50 MG
Propargyl-PEG7-acid is a polyethylene glycol (PEG)-based linker with a terminal propargyl (alkyne) group and a carboxylic acid. It is used as a click-chemistry compatible linker for assembling PROTACs and antibody-drug conjugates, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach payloads or targeting moieties.
- Cleavable PEG linker suitable for PROTAC and ADC synthesis.
- Contains a terminal alkyne for CuAAC (click chemistry) conjugation.
- High purity supports reliable coupling reactions.
- Stable as a dry powder when stored under inert atmosphere at low temperature.
- Available in small research packs for medicinal chemistry use.
eMolecules 3-Ethoxy-5-(trifluoromethoxy)phenylboronic acid | 1256345-87-5 | MFCD16295059 | 1g
Combi-Blocks | 3-Ethoxy-5-(trifluoromethoxy)phenylboronic acid | 1g | 117524556 | BB-6330 | 97.000 | 1256345-87-5 | MFCD16295059 | 249.980 | C9H10BF3O4
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Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 500 MG
Propargyl-PEG3-bromide is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG3-OCH2-Boc | 888010-02-4 | 302.36 | 50 MG
Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. This compound is strictly for research use and is not intended for patient treatment.
- PEG-based PROTAC linker for PROTAC synthesis
- Click chemistry reagent with Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups
- Chemical formula: C15H26O6
- Intended for research use only
Medchemexpress LLC Propargyl-PEG10-acid | 2055022-18-7 | 98.0% | 524.60 | 250 MG
Propargyl-PEG10-acid is a PEG derivative containing a propargyl group with a terminal carboxylic acid. It functions as a click chemistry reagent, utilizing an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing azide groups.
- PEG derivative
- Contains a propargyl group
- Features a terminal carboxylic acid
- Functions as a click chemistry reagent
- Enables copper-catalyzed azide-alkyne cycloaddition with azide groups
Medchemexpress LLC Propargyl-PEG1-SS-PEG1-C2-Boc | 1807518-78-0 | >96.0% | 320.46 g/mol | C14H24O4S2 | 5 MG
Propargyl-PEG1-SS-PEG1-C2-Boc is a cleavable PEG-based linker that contains a propargyl alkyne group, a disulfide (SS) bond, and a Boc-protected terminus. It is used in bioconjugation workflows such as antibody-drug conjugate (ADC) and PROTAC linker synthesis, and enables click chemistry (CuAAC) and redox-sensitive payload release.
- Cleavable disulfide bond enabling redox-sensitive release.
- Terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Boc-protected terminus allows orthogonal deprotection and functionalization.
- One-unit PEG spacer improves solubility and linker flexibility.
- Supplied in small research-scale quantities for conjugation workflows.
eMolecules Propargyl-PEG6-alcohol | 1036204-60-0 | MFCD27635181 | 1g
Broadpharm | Propargyl-PEG6-alcohol | 1g | 229582392 | BP-22010 | 98.000 | 1036204-60-0 | MFCD27635181 | 276.329 | C13H24O6
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Medchemexpress LLC Bis-propargyl-PEG4 | 159428-42-9 | 95.6% | 5 G
Bis-propargyl-PEG4 is a PEG-based bifunctional linker featuring terminal propargyl (alkyne) groups, designed for conjugation chemistry and PROTAC construction. It provides a short, flexible spacer for joining two ligands via click chemistry.
- Bifunctional PEG4 linker with terminal alkyne groups.
- Enables copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Useful for PROTAC synthesis and dimer formation.
- Low molecular weight (270.32 g/mol) for compact linker design.
- Stable under recommended storage conditions when kept dry and refrigerated.