Lignans and related compounds
Apexbio Technology LLC Etoposide 33419-42-0 10mM (in 1mL DMSO)
Etoposide (VP-16) is a topoisomerase II inhibitor widely used in biomedical research to study mechanisms of DNA damage and cancer therapy It forms a stabilized complex with DNA and topoisomerase II preventing the enzyme-mediated religation of cleaved DNA strands Resulting DNA double-strand breaks lead to apoptosis particularly in rapidly dividing cancer cells Reported IC50 values vary across cell lines such as 59 2 M for topoisomerase II inhibition 30 16 M in HepG2 and 0 051 M for MOLT-3 indicating differential cytotoxic responses to etoposide in various cancer cell models
Medchemexpress LLC Etoposide | 33419-42-0 | 99.6% | 588.56 | 500 MG
Etoposide (Standard) is the analytical standard of Etoposide, designed for research and analytical applications. It functions as an anti-cancer chemotherapy agent by inhibiting topoisomerase II, which halts DNA replication. This action leads to the induction of cell cycle arrest, apoptosis, and autophagy. As an analytical standard, the compound is frequently utilized in qualitative, quantitative, and methodological research experiments, including techniques such as HPLC, GC, and MS.
- Inhibits topoisomerase II
- Halts DNA replication
- Induces cell cycle arrest, apoptosis, and autophagy
- Utilized in qualitative, quantitative, and methodological research experiments
- Suitable for techniques such as HPLC, GC, and MS